Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

P-TEFb-cap methyltransferase complex

Known as: P-TEFb-Pcm1 complex, P-TEFb-Pcm1 complex location, P-TEFb-cap methyltransferase complex location 
A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping… Expand
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2007
Review
2007
The Double Bromodomain-containing Chromatin Adaptor Brd4 and Transcriptional Regulation*
Brd4 is a double bromodomain-containing protein that binds preferentially to acetylated chromatin. It belongs to the BET… Expand
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
Highly Cited
2005
Highly Cited
2005
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.
  • Z. Yang, J. Yik, +4 authors Qiang Zhou
  • Molecular cell
  • 2005
    • Corpus ID: 25239828
The cyclinT1/Cdk9 heterodimer that constitutes core P-TEFb is generally presumed to be the transcriptionally active form for… Expand
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Inhibition of P-TEFb (CDK9/Cyclin T) kinase and RNA polymerase II transcription by the coordinated actions of HEXIM1 and 7SK snRNA.
The positive transcriptional elongation factor b (P-TEFb), consisting of CDK9 and cyclin T, stimulates transcription by… Expand
Is this relevant?
Highly Cited
2001
Highly Cited
2001
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
The human positive transcription elongation factor P-TEFb, consisting of a CDK9/cyclin T1 heterodimer, functions as both a… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2001
Highly Cited
2001
Flavopiridol Inactivates P-TEFb and Blocks Most RNA Polymerase II Transcription in Vivo *
  • S. Chao, D. Price
  • The Journal of Biological Chemistry
  • 2001
    • Corpus ID: 25333906
Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor in clinical trials as a cancer therapy that has… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
P-TEFb kinase recruitment and function at heat shock loci.
P-TEFb, a heterodimer of the kinase Cdk9 and cyclin T, was isolated as a factor that stimulates formation of productive… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Flavopiridol Inhibits P-TEFb and Blocks HIV-1 Replication*
Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor that is in clinical trials as a cancer treatment… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Transcription elongation factor P-TEFb is required for HIV-1 tat transactivation in vitro.
P-TEFb is a key regulator of the process controlling the processivity of RNA polymerase II and possesses a kinase activity that… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
P-TEFb kinase is required for HIV Tat transcriptional activation in vivo and in vitro.
To identify novel inhibitors of transcriptional activation by the HIV Tat protein, we used a combination of in vitro and in vivo… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • table 1
Is this relevant?
Highly Cited
1995
Highly Cited
1995
Purification of P-TEFb, a Transcription Factor Required for the Transition into Productive Elongation (*)
Production of full-length runoff transcripts in vitro and functional mRNA in vivo is sensitive to the drug 5,6-dichloro-1-β-D… Expand
Is this relevant?
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License
ACCEPT & CONTINUE