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P-TEFb-cap methyltransferase complex

Known as: P-TEFb-Pcm1 complex, P-TEFb-Pcm1 complex location, P-TEFb-cap methyltransferase complex location 
A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping… 
National Institutes of Health

Papers overview

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2016
2016
DDX6 transfers P-TEFb kinase to the AF4/AF4N (AFF1) super elongation complex.
AF4/AFF1 and AF5/AFF4 are both backbones for the assembly of "super elongation complexes" (SECs) that exert 2 distinct functions… 
2011
2011
HMGA1-dependent and independent 7SK RNA gene regulatory activity
The small nuclear 7SK RNA negatively controls transcription by inactivating positive transcription elongation factor b (P-TEFb… 
2009
2009
ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC
BackgroundThe nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills… 
Review
2008
Review
2008
RNA‐driven cyclin‐dependent kinase regulation: When CDK9/cyclin T subunits of P‐TEFb meet their ribonucleoprotein partners
The positive transcription elongation factor (P‐TEFb) consists of CDK9, a cyclin‐dependent kinase and its cyclin T partner. It is… 
2006
2006
Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation
The HEXIM1 protein, in association with 7SK snRNA, binds and inhibits the kinase activity of P‐TEFb (CDK9/cyclin T). P‐TEFb… 
2006
2006
Cyclin T1 but not cyclin T2a is induced by a post‐transcriptional mechanism in PAMP‐activated monocyte‐derived macrophages
Positive transcription elongation factor b (P‐TEFb) is an RNA polymerase II elongation factor which exists as multiple complexes… 
Highly Cited
2005
Highly Cited
2005
Transcription-dependent Association of Multiple Positive Transcription Elongation Factor Units to a HEXIM Multimer*
The positive transcription elongation factor (P-TEFb) comprises a kinase, CDK9, and a Cyclin T1 or T2. Its activity is inhibited… 
Review
2003
Review
2003
Cyclin-dependent kinase inhibitors.
  • Yun DaiS. Grant
  • Current opinion in pharmacology (Print)
  • 2003
  • Corpus ID: 11869074
Cell-cycle dysregulation is one of the cardinal characteristics of neoplastic cells. For this reason, small molecule inhibitors… 
Highly Cited
2002
Highly Cited
2002
P-TEFb Containing Cyclin K and Cdk9 Can Activate Transcription via RNA*
Different positive transcription elongation factor b (P-TEFb) complexes isolated from mammalian cells contain a common catalytic… 
Highly Cited
1999
Highly Cited
1999
Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication.
HIV-1 gene expression and viral replication require the viral transactivator protein Tat. The RNA polymerase II transcriptional… 
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