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P-TEFb-cap methyltransferase complex
Known as:
P-TEFb-Pcm1 complex
, P-TEFb-Pcm1 complex location
, P-TEFb-cap methyltransferase complex location
A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
DDX6 transfers P-TEFb kinase to the AF4/AF4N (AFF1) super elongation complex.
Fabian Mück
,
S. Bracharz
,
R. Marschalek
American Journal of Blood Research
2016
Corpus ID: 39626813
AF4/AFF1 and AF5/AFF4 are both backbones for the assembly of "super elongation complexes" (SECs) that exert 2 distinct functions…
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2011
2011
HMGA1-dependent and independent 7SK RNA gene regulatory activity
Sebastian Eilebrecht
,
C. Bécavin
,
H. Léger
,
B. Benecke
,
A. Benecke
RNA Biology
2011
Corpus ID: 12118137
The small nuclear 7SK RNA negatively controls transcription by inactivating positive transcription elongation factor b (P-TEFb…
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2009
2009
ARC (NSC 188491) has identical activity to Sangivamycin (NSC 65346) including inhibition of both P-TEFb and PKC
L. Stockwin
,
Sherry X. Yu
,
H. Stotler
,
M. Hollingshead
,
D. Newton
BMC Cancer
2009
Corpus ID: 13119720
BackgroundThe nucleoside analog, ARC (NSC 188491) is a recently characterized transcriptional inhibitor that selectively kills…
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Review
2008
Review
2008
RNA‐driven cyclin‐dependent kinase regulation: When CDK9/cyclin T subunits of P‐TEFb meet their ribonucleoprotein partners
A. Michels
,
O. Bensaude
Biotechnology Journal
2008
Corpus ID: 7042117
The positive transcription elongation factor (P‐TEFb) consists of CDK9, a cyclin‐dependent kinase and its cyclin T partner. It is…
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2006
2006
Increased HEXIM1 expression during erythroleukemia and neuroblastoma cell differentiation
M. Turano
,
G. Napolitano
,
C. Dulac
,
B. Majello
,
O. Bensaude
,
L. Lania
Journal of Cellular Physiology
2006
Corpus ID: 24392601
The HEXIM1 protein, in association with 7SK snRNA, binds and inhibits the kinase activity of P‐TEFb (CDK9/cyclin T). P‐TEFb…
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2006
2006
Cyclin T1 but not cyclin T2a is induced by a post‐transcriptional mechanism in PAMP‐activated monocyte‐derived macrophages
Li‐Ying Liou
,
Richard E Haaland
,
C. Herrmann
,
A. P. Rice
Journal of Leukocyte Biology
2006
Corpus ID: 3257673
Positive transcription elongation factor b (P‐TEFb) is an RNA polymerase II elongation factor which exists as multiple complexes…
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Highly Cited
2005
Highly Cited
2005
Transcription-dependent Association of Multiple Positive Transcription Elongation Factor Units to a HEXIM Multimer*
C. Dulac
,
A. Michels
,
+5 authors
O. Bensaude
Journal of Biological Chemistry
2005
Corpus ID: 25319838
The positive transcription elongation factor (P-TEFb) comprises a kinase, CDK9, and a Cyclin T1 or T2. Its activity is inhibited…
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Review
2003
Review
2003
Cyclin-dependent kinase inhibitors.
Yun Dai
,
S. Grant
Current opinion in pharmacology (Print)
2003
Corpus ID: 11869074
Cell-cycle dysregulation is one of the cardinal characteristics of neoplastic cells. For this reason, small molecule inhibitors…
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Highly Cited
2002
Highly Cited
2002
P-TEFb Containing Cyclin K and Cdk9 Can Activate Transcription via RNA*
Xin Lin
,
R. Taube
,
K. Fujinaga
,
B. Peterlin
Journal of Biological Chemistry
2002
Corpus ID: 25592568
Different positive transcription elongation factor b (P-TEFb) complexes isolated from mammalian cells contain a common catalytic…
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Highly Cited
1999
Highly Cited
1999
Host-cell positive transcription elongation factor b kinase activity is essential and limiting for HIV type 1 replication.
Osvaldo Flores
,
Gary Lee
,
+4 authors
Daria J. Hazuda
Proceedings of the National Academy of Sciences…
1999
Corpus ID: 28272375
HIV-1 gene expression and viral replication require the viral transactivator protein Tat. The RNA polymerase II transcriptional…
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