P-TEFb-cap methyltransferase complex

Known as: P-TEFb-Pcm1 complex, P-TEFb-Pcm1 complex location, P-TEFb-cap methyltransferase complex location 
A protein complex that is formed by the association of positive transcription elongation factor complex b (P-TEFb) with the mRNA capping… (More)
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.
The cyclinT1/Cdk9 heterodimer that constitutes core P-TEFb is generally presumed to be the transcriptionally active form for… (More)
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Highly Cited
2004
Highly Cited
2004
Dynamics of human immunodeficiency virus transcription: P-TEFb phosphorylates RD and dissociates negative effectors from the transactivation response element.
The elongation of transcription is a highly regulated process that requires negative and positive effectors. By binding the… (More)
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Highly Cited
2003
Highly Cited
2003
c-Myc recruits P-TEFb for transcription, cellular proliferation and apoptosis
c-Myc promotes cellular proliferation, sensitizes cells to apoptosis and prevents differentiation. It binds cyclin T1… (More)
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Highly Cited
2001
Highly Cited
2001
NF-kappaB binds P-TEFb to stimulate transcriptional elongation by RNA polymerase II.
To stimulate transcriptional elongation of HIV-1 genes, the transactivator Tat recruits the positive transcription elongation… (More)
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Highly Cited
2001
Highly Cited
2001
Flavopiridol inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo.
Flavopiridol (L86-8275, HMR1275) is a cyclin-dependent kinase (Cdk) inhibitor in clinical trials as a cancer therapy that has… (More)
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Highly Cited
2001
Highly Cited
2001
The 7SK small nuclear RNA inhibits the CDK9/cyclin T1 kinase to control transcription
The human positive transcription elongation factor P-TEFb, consisting of a CDK9/cyclin T1 heterodimer, functions as both a… (More)
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Highly Cited
2001
Highly Cited
2001
7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes
The transcription of eukaryotic protein-coding genes involves complex regulation of RNA polymerase (Pol) II activity in response… (More)
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Highly Cited
2000
Highly Cited
2000
P-TEFb kinase recruitment and function at heat shock loci.
P-TEFb, a heterodimer of the kinase Cdk9 and cyclin T, was isolated as a factor that stimulates formation of productive… (More)
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Highly Cited
1998
Highly Cited
1998
Evidence that P-TEFb alleviates the negative effect of DSIF on RNA polymerase II-dependent transcription in vitro.
Recently, a positive and a negative elongation factor, implicated in 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB… (More)
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Highly Cited
1995
Highly Cited
1995
Purification of P-TEFb, a transcription factor required for the transition into productive elongation.
Production of full-length runoff transcripts in vitro and functional mRNA in vivo is sensitive to the drug 5,6-dichloro-1-beta-D… (More)
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