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Transcriptional regulation by the Sp family proteins.
TLDR
This review focuses primarily on strategies aimed to elucidate the transcription properties of the Sp1-like factors and discusses the experimental problems inherent in the attempt to define their respective functions. Expand
LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription
TLDR
The role of transient LSD1-mediated demethylation of H3K4 leading to local DNA oxidation as driving force in the assembly of the Myc-induced transcription initiation complex is highlighted. Expand
A Novel Member of the BTB/POZ Family, PATZ, Associates with the RNF4 RING Finger Protein and Acts as a Transcriptional Repressor*
TLDR
A novel human gene encoding a 59-kDa POZ-AT hook-zinc finger protein (PATZ) that interacts with RNF4, a mediator of androgen receptor activity, and acts as a transcriptional repressor is identified. Expand
Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo
TLDR
It is determined that, unlike conventional activators, DNA-bound CDK9 does not activate enhancerless TATA-promoters unless TBP is overexpressed, suggesting that CDK 9 acts in vivo at a step subsequent to TFIID recruitment DNA- bound. Expand
Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression Domains*
TLDR
It is demonstrated that Sp3 is a bifunctional transcription factor that can both activate and repress transcription, and the repression activity is strictly dependent on the context of the DNA-binding sites bound by Sp3. Expand
Constitutive and IL‐6‐induced nuclear factors that interact with the human C‐reactive protein promoter.
TLDR
A synthetic promoter based on the multimerization of the beta‐binding domain, but not of the alpha‐domain, is highly inducible when transfected in hepatoma cells and is discussed in relation to the structure of the promoter region of other acute phase inducable genes. Expand
Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.
TLDR
It is demonstrated that Sp4 is an activator, while the Sp3 protein represses basal expression of HIV promoter, and over-expression of the transcription factor Sp3 was able to suppress Tat-mediated transactivation. Expand
The histone LSD1 demethylase in stemness and cancer transcription programs.
TLDR
Recent insights on the role of LSD1 activity in chromatin regulatory complexes, its functional role in the epigenetic changes during embryonic development, in the establishment and maintenance of stemness and during cancer progression are reviewed. Expand
Myc and PI3K/AKT signaling cooperatively repress FOXO3a-dependent PUMA and GADD45a gene expression
TLDR
It is shown here that Myc significantly and selectively contributes to repression of FOXO-mediated expression of PUMA and GADD45a, and that in Myc deprived cells inhibition of PUma and Gadd45a following serum stimulation is impaired and that MyC does not interfere with p53 induction ofPUMA transcription. Expand
Human c-myb protooncogene: nucleotide sequence of cDNA and organization of the genomic locus.
TLDR
Identification of 5' and 3' coding and noncoding exons indicates that the human c-myb locus spans a 40-kilobase region, which may represent a functionally important structure, most likely the DNA-binding domain. Expand
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