• Publications
  • Influence
Binding of the 7SK snRNA turns the HEXIM1 protein into a P‐TEFb (CDK9/cyclin T) inhibitor
TLDR
An in vitro reconstitution of 7SK‐dependent HEXIM1 association to purified P‐TEFb and subsequent CDK9 inhibition is reported and it is proposed that the RNA‐binding domain of HexIM1 mediates its association with 7SK and that P‐ TEFb then enters the complex through association with H EXIM1. Expand
MAQ1 and 7SK RNA Interact with CDK9/Cyclin T Complexes in a Transcription-Dependent Manner
TLDR
It is speculated that the TAR RNA/Tat lentivirus system has evolved to subvert the cellular 7SK RNA/MAQ1 system. Expand
Class A helix-loop-helix proteins are positive regulators of several cyclin-dependent kinase inhibitors' promoter activity and negatively affect cell growth.
TLDR
The role of the class A bHLH proteins as general negative regulators of cell proliferation through a mechanism(s) that involves both enhancement of several cyclin-dependent kinase inhibitor genes expression and promotion of cell death is highlighted. Expand
Transcriptional regulation by the Sp family proteins.
TLDR
This review focuses primarily on strategies aimed to elucidate the transcription properties of the Sp1-like factors and discusses the experimental problems inherent in the attempt to define their respective functions. Expand
LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription
TLDR
The role of transient LSD1-mediated demethylation of H3K4 leading to local DNA oxidation as driving force in the assembly of the Myc-induced transcription initiation complex is highlighted. Expand
A Novel Member of the BTB/POZ Family, PATZ, Associates with the RNF4 RING Finger Protein and Acts as a Transcriptional Repressor*
TLDR
A novel human gene encoding a 59-kDa POZ-AT hook-zinc finger protein (PATZ) that interacts with RNF4, a mediator of androgen receptor activity, and acts as a transcriptional repressor is identified. Expand
Transcriptional regulation by targeted recruitment of cyclin-dependent CDK9 kinase in vivo
TLDR
It is determined that, unlike conventional activators, DNA-bound CDK9 does not activate enhancerless TATA-promoters unless TBP is overexpressed, suggesting that CDK 9 acts in vivo at a step subsequent to TFIID recruitment DNA- bound. Expand
Transcription-dependent Association of Multiple Positive Transcription Elongation Factor Units to a HEXIM Multimer*
TLDR
Hydrodynamic parameters measured by glycerol gradient ultracentrifugation and gel-permeation chromatography demonstrate that both purified recombinant and cellular HEXIM1 proteins form highly anisotropic particles. Expand
Sp3 Is a Bifunctional Transcription Regulator with Modular Independent Activation and Repression Domains*
TLDR
It is demonstrated that Sp3 is a bifunctional transcription factor that can both activate and repress transcription, and the repression activity is strictly dependent on the context of the DNA-binding sites bound by Sp3. Expand
Different members of the Sp1 multigene family exert opposite transcriptional regulation of the long terminal repeat of HIV-1.
TLDR
It is demonstrated that Sp4 is an activator, while the Sp3 protein represses basal expression of HIV promoter, and over-expression of the transcription factor Sp3 was able to suppress Tat-mediated transactivation. Expand
...
1
2
3
4
5
...