Semantic Scholar uses AI to extract papers important to this topic.
Inactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiation; inactivation of Lrp5, a gene… Expand Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone… Expand Osteoclasts are the principal, if not exclusive, bone-resorbing cells, and their activity has a profound impact on skeletal… Expand Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos… Expand Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in skeletal turnover so that bone resorption… Expand The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice. RANK… Expand The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal… Expand Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage… Expand We previously reported that osteoclast-like cells were formed in cocultures of a mouse marrow-derived stromal cell line (ST2… Expand A key event in bone resorption is the binding of osteoclasts to the mineral matrix of bone surfaces. A candidate for mediating… Expand