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Osteoclasts

Known as: Osteoclast 
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an… Expand
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts… Expand
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Highly Cited
2005
Highly Cited
2005
Inactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiation; inactivation of Lrp5, a gene… Expand
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Review
2003
Review
2003
Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone… Expand
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Review
2003
Review
2003
Osteoclasts are the principal, if not exclusive, bone-resorbing cells, and their activity has a profound impact on skeletal… Expand
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Highly Cited
2002
Highly Cited
2002
Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos… Expand
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Review
2000
Review
2000
Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in skeletal turnover so that bone resorption… Expand
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Review
1999
Review
1999
Osteoblasts/stromal cells are essentially involved in osteoclast differentiation and function through cell-to-cell contact (Fig… Expand
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Highly Cited
1999
Highly Cited
1999
A receptor that mediates osteoprotegerin ligand (OPGL)-induced osteoclast differentiation and activation has been identified via… Expand
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Highly Cited
1998
Highly Cited
1998
The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal… Expand
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Highly Cited
1998
Highly Cited
1998
Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage… Expand
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