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Osteoclasts

Known as: Osteoclast 
A large multinuclear cell associated with the BONE RESORPTION. An odontoclast, also called cementoclast, is cytomorphologically the same as an… Expand
National Institutes of Health

Papers overview

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Highly Cited
2005
Highly Cited
2005
Inactivation of beta-catenin in mesenchymal progenitors prevents osteoblast differentiation; inactivation of Lrp5, a gene… Expand
Review
2003
Review
2003
Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone… Expand
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Review
2003
Review
2003
Osteoclasts are the principal, if not exclusive, bone-resorbing cells, and their activity has a profound impact on skeletal… Expand
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Highly Cited
2002
Highly Cited
2002
Signaling by RANKL is essential for terminal differentiation of monocytes/macrophages into osteoclasts. The TRAF6 and c-Fos… Expand
Review
2000
Review
2000
Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in skeletal turnover so that bone resorption… Expand
Highly Cited
1999
Highly Cited
1999
The physiological role of the TNF receptor (TNFR) family member, RANK, was investigated by generating RANK-deficient mice. RANK… Expand
Highly Cited
1998
Highly Cited
1998
The ligand for osteoprotegerin has been identified, and it is a TNF-related cytokine that replaces the requirement for stromal… Expand
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Highly Cited
1998
Highly Cited
1998
Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage… Expand
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Highly Cited
1990
Highly Cited
1990
We previously reported that osteoclast-like cells were formed in cocultures of a mouse marrow-derived stromal cell line (ST2… Expand
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Highly Cited
1990
Highly Cited
1990
A key event in bone resorption is the binding of osteoclasts to the mineral matrix of bone surfaces. A candidate for mediating… Expand
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