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Frzb, a Secreted Protein Expressed in the Spemann Organizer, Binds and Inhibits Wnt-8
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Multipotent mesenchymal stem cells from adult human synovial membrane.
TLDR
It is demonstrated that human multipotent MSCs can be isolated from the SM of knee joints and have the ability to proliferate extensively in culture, and they maintain their multilineage differentiation potential in vitro, establishing their progenitor cell nature.
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Treatment of Symptomatic Cartilage Defects of the Knee
TLDR
Characterized chondrocyte implantation for the treatment of articular cartilage defects of the femoral condyles of the knee results in significantly better clinical outcome at 36 months in a randomized trial compared with MF.
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Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components.
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Characterized Chondrocyte Implantation Results in Better Structural Repair When Treating Symptomatic Cartilage Defects of the Knee in a Randomized Controlled Trial versus Microfracture
TLDR
One year after treatment, characterized chondrocyte implantation was associated with a tissue regenerate that was superior to that after microfracture, and the superior structural outcome may result in improved long-term clinical benefit with characterized chontological implantation.
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Mechanisms of GDF-5 action during skeletal development.
TLDR
The data show that levels of GDF-5 expression/activity are important in controlling the size of skeletal elements and provides a possible explanation for the variation in the severity of skeletal defects resulting from mutations in G DF-5.
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Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane
TLDR
Adult human synovial membrane-derived mesenchymal stem cells (hSM-MSCs) have myogenic differentiation in a nude mouse model of skeletal muscle regeneration and proof of principle of their potential use for muscle repair in the mdx mice model of Duchenne muscular dystrophy is provided.
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The bone–cartilage unit in osteoarthritis
TLDR
Several molecular signaling pathways such as bone morphogenetic proteins and Wnts are hypothesized to have a role in OA and can activate cellular and molecular processes in both cartilage and bone cells, which could lead to the development of specific therapeutics or treatment strategies.
View on Nature
Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis.
TLDR
It is reported that this process partially recapitulates embryonic endochondral bone formation in a spontaneous model of arthritis in DBA/1 mice, suggesting that BMP signaling is an attractive therapeutic target for interfering with structural changes in spondyloarthropathy either as an alternative or complementary approach to current antiinflammatory treatments.
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Definition and classification of early osteoarthritis of the knee
TLDR
To better identify the patients at risk and responders to certain treatments, it is of use to define and most importantly classify patients with “early osteoarthritis”.
View on Springer
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