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Bone remodeling depends on the precise coordination of bone resorption and subsequent bone formation. Disturbances of this… Expand Bone remodelling, the mechanism by which vertebrates regulate bone mass, comprises two phases, namely resorption by osteoclasts… Expand Osteoporosis, a disease endemic in Western society, typically reflects an imbalance in skeletal turnover so that bone resorption… Expand Although multiple hormones and cytokines regulate various aspects of osteoclast formation, the final two effectors are… Expand A novel secreted glycoprotein that regulates bone resorption has been identified. The protein, termed Osteoprotegerin (OPG), is a… Expand Increased bone turnover has been suggested as a potential risk factor for osteoporotic fractures. We investigated this hypothesis… Expand To examine the possible involvement of IL-6 in bone metabolism, a mouse osteoblastic cell line (MC3T3-E1) and primary osteoblast… Expand Bone resorption depends on the formation, by osteoclasts, of an acidic extracellular compartment wherein matrix is degraded. The… Expand When leukocytes are exposed to mitogens or antigens in vitro, they release bone-resorbing activity into the culture supernatants… Expand Many activities are now ascribed to the monokine interleukin 11 including enhancement of immune responses, stimulation of… Expand