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Tetracyclines inhibit connective tissue breakdown: new therapeutic implications for an old family of drugs.
Tetracyclines have long been considered useful adjuncts in peridontal therapy based on their antimicrobial efficacy against putative periodontopathogens. However, recently these drugs were found toExpand
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A ryanodine receptor-like molecule expressed in the osteoclast plasma membrane functions in extracellular Ca2+ sensing.
Ryanodine receptors (RyRs) reside in microsomal membranes where they gate Ca2+ release in response to changes in the cytosolic Ca2+ concentration. In the osteoclast, a divalent cation sensor, theExpand
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Reactive oxygen species activate and tetracyclines inhibit rat osteoblast collagenase
Recent studies have demonstrated that tetracyclines (TCs) scavenge reactive oxygen species (ROS). Hypochlorous acid (HOCI), an ROS produced by neutrophils, has been shown to activate neutrophilExpand
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Inhibition of matrix metalloproteinase-mediated periodontal bone loss in rats: a comparison of 6 chemically modified tetracyclines.
BACKGROUND Chemically modified tetracyclines (CMTs), devoid of antimicrobial activity, inhibit pathologically elevated collagenase activity both in vivo and in vitro. In the current study,Expand
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Cathepsin B and L activities in isolated osteoclasts.
Cathepsin B and L activities were examined with chicken osteoclasts isolated by sequential filtration and inhibitors were added to disaggregated rat osteoclasts on cortical bovine bone.Expand
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A combination of a chemically modified doxycycline and a bisphosphonate synergistically inhibits endotoxin-induced periodontal breakdown in rats.
BACKGROUND Chemically modified non-antimicrobial tetracyclines (CMTs) have been shown to inhibit pathologically elevated collagenase (and other matrix metalloproteinase, MMP) activity and boneExpand
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Blocking periodontal disease progression by inhibiting tissue-destructive enzymes: a potential therapeutic role for tetracyclines and their chemically-modified analogs.
Tetracyclines (TCs) have wide therapeutic usage as antimicrobial agents; these drugs (e.g., minocycline, doxycycline) remain useful as adjuncts in periodontal therapy. However, TCs also haveExpand
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The lipophilicity, pharmacokinetics, and cellular uptake of different chemically-modified tetracyclines (CMTs).
CMTs are analogs of tetracyclines, which are chemically modified to eliminate their antimicrobial efficacy but which retain their inhibitory activity against matrix metalloproteinases. TheseExpand
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Halitosis. A common oral problem.
Halitosis is caused primarily by bacterial putrefaction and the generation of volatile sulfur compounds. Ninety percent of patients suffering from halitosis have oral causes, such as poor oralExpand
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Biology and Physiology of the Osteoclast
Experimental Systems for Studying Osteoclast Biology (P. Osdoby, M. Krukowski, and P. Collin-Osdoby). Antigenic Markers of Osteoclasts (M.A. Horton and M.H. Helfrich). Acid Phosphatases (G.Expand
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