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Insulin Signaling in Osteoblasts Integrates Bone Remodeling and Energy Metabolism
It is shown here that insulin signaling in osteoblasts is necessary for whole-body glucose homeostasis because it increases osteocalcin activity, which promotes glucose metabolism in a bone resorption-dependent manner in mice and humans.
Osteoclast-poor human osteopetrosis due to mutations in the gene encoding RANKL
Autosomal recessive osteopetrosis is usually associated with normal or elevated numbers of nonfunctional osteoclasts. Here we report mutations in the gene encoding RANKL (receptor activator of
Chloride Channel ClCN7 Mutations Are Responsible for Severe Recessive, Dominant, and Intermediate Osteopetrosis
Among 94 osteopetrotic patients presenting with a severe clinical picture and diagnosed early in life, 12 bore mutations in the ClCN7 gene, but only 7 of them had the expected two recessive
Decreased C-Src Expression Enhances Osteoblast Differentiation and Bone Formation
It is concluded that the reduction of Src expression not only inhibits bone resorption, but also stimulates osteoblast differentiation and bone formation, suggesting that the osteogenic cells may contribute to the development of the osteopetrotic phenotype in Src-deficient mice.
Cell-substratum interaction of cultured avian osteoclasts is mediated by specific adhesion structures
This form of cell-substratum contact occurring at the tip of a short ventral protrusion represented an osteoclast-specific adhesion device that might also be present in in vivo osteoclasts as well as in other normal and transformed cell types.
Rous sarcoma virus-transformed fibroblasts and cells of monocytic origin display a peculiar dot-like organization of cytoskeletal proteins involved in microfilament-membrane interactions.
It is concluded that RSV transformation induces fibroblasts to express a cytoskeletal organization and a pattern of adhesion that are normally found in cells of monocytic origin and it is proposed that the occurrence of this cytoskeleton organization in RSV-transformed fibro Blasts and in monocyte-derived cells may reflect a common ability to migrate across anatomical boundaries.
Osteoclast cytosolic calcium, regulated by voltage-gated calcium channels and extracellular calcium, controls podosome assembly and bone resorption
The mechanisms of Ca2+ entry and their effects on cell function were investigated in cultured chicken osteoclasts and putative osteoclasts produced by fusion of mononuclear cell precursors.
Genetics, pathogenesis and complications of osteopetrosis.
It is demonstrated that osteoblasts may also contribute to the pathogenesis of the disease, either because they are affected by intrinsic defects, or because their activity may be enhanced by deregulated osteoclasts abundantly present in most forms, thus suggesting additional genetic/environmental determinants affecting penetrance.
The selective estrogen receptor modulator raloxifene regulates osteoclast and osteoblast activity in vitro.
Data show that raloxifene negatively modulates osteoclasts, and positively affects osteoblasts, suggesting not only an antiresorptive role, but also an osteoblast stimulatory role.
Impaired gastric acidification negatively affects calcium homeostasis and bone mass
The results suggest that alterations in calcium homeostasis can be driven by defects in gastric acidification, especially given that calcium gluconate supplementation fully rescues the phenotype of the Cckbr-mutant mice.