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Oprelvekin

Known as: Recombinant Human Interleukin-11, Adipogenesis Inhibitory Factor, AGIF 
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone… 
National Institutes of Health

Related topics

Related topics

12 relations

Broader (3)

Antineoplastic AgentsInterleukin-11Recombinant Proteins
Drug AllergyIL11 geneIL11 protein, humanInhibition of Cell Proliferation

Narrower (1)

Neumega

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2001
Highly Cited
2001
Pilot study of low-dose interleukin-11 in patients with bone marrow failure.
PURPOSE Interleukin-11 (IL-11) is a thrombopoietic cytokine that attenuates postchemotherapy thrombocytopenia at doses of 50… 
Highly Cited
1999
Highly Cited
1999
Interleukin‐11 reduces T‐cell–dependent experimental liver injury in mice
Recombinant human interleukin‐11 (rhIL‐11) is a multifunctional cytokine that can reduce inflammation through the downregulation… 
Highly Cited
1999
Highly Cited
1999
Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal…
We recently characterized leukemia inhibitory factor (LIF) as an important modulator of hypothalamo-pituitary-adrenal (HPA) axis… 
Highly Cited
1999
Highly Cited
1999
Hepatocyte growth factor (HGF) induces interleukin-11 secretion from osteoblasts: a possible role for HGF in myeloma-associated osteolytic bone disease.
Multiple myeloma is associated with unbalanced bone remodeling causing lytic bone lesions. Interleukin-11 (IL-11) promotes… 
Highly Cited
1997
Highly Cited
1997
Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and…
PURPOSE Thrombocytopenia may compromise cancer treatment, causing chemotherapy dose reductions, schedule alterations, or the need… 
Highly Cited
1996
Highly Cited
1996
Interleukin‐4 inhibits prostaglandin G/H synthase‐2 and cytosolic phospholipase A2 induction in neonatal mouse parietal bone cultures
We have shown previously that prostaglandin (PG) production in 7‐day‐old neonatal mouse calvarial cultures is regulated largely… 
Highly Cited
1996
Highly Cited
1996
Functional Expression of Soluble Human Interleukin-11 (IL-11) Receptor α and Stoichiometry of in Vitro IL-11 Receptor Complexes with gp130*
The interleukin-6 (IL-6) family of cytokines activates signaling through the formation of either gp130 homodimers, as for IL-6… 
Highly Cited
1995
Highly Cited
1995
Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11.
Interleukin-11 (IL-11) is a stromal cell-derived cytokine with multiple biologic activities on lymphohematopoietic cells. It… 
Highly Cited
1994
Highly Cited
1994
Recombinant human interleukin-11 stimulates multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin.
Interleukin-11 (IL-11) is a novel multifunctional hematopoietic cytokine capable of stimulating cells of the myeloid, lymphoid… 
Highly Cited
1992
Highly Cited
1992
Interleukin-11 stimulates multiple phases of erythropoiesis in vitro.
Interleukin-11 (IL-11), a pleiotropic cytokine originally isolated from a primate bone marrow stromal cell line, has been shown… 
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