Oprelvekin

Known as: Recombinant Human Interleukin-11, Adipogenesis Inhibitory Factor, AGIF 
A recombinant therapeutic agent which is chemically identical to or similar to the endogenous cytokine interleukin 11 (IL-11). Secreted by bone… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Chemotherapy resistance frequently drives tumour progression. However, the underlying molecular mechanisms are poorly… (More)
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Highly Cited
2013
Highly Cited
2013
Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through… (More)
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Highly Cited
2010
Highly Cited
2010
OBJECTIVE The purpose of this study was to identify genetic variants underlying the considerable individual differences in… (More)
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Highly Cited
2007
Highly Cited
2007
Melanoma has a propensity to metastasize to bone, where it is exposed to high concentrations of transforming growth factor-beta… (More)
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Highly Cited
2003
Highly Cited
2003
Interleukin-6 (IL-6) and interleukin-11 (IL-11) are known to influence osteoclast formation and bone resorption. In order to… (More)
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Highly Cited
1999
Highly Cited
1999
Osteoblastic stromal cells are capable of supporting osteoclast formation from hematopoietic precursors in the presence of… (More)
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Highly Cited
1998
Highly Cited
1998
The osteoclastogenic factor of osteoblastic origin has recently been elucidated as a novel Tumor Necrosis Factor (TNF)-ligand… (More)
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Highly Cited
1998
Highly Cited
1998
Administration of IL-11 prevented lethal graft-versus-host disease (GVHD) in a murine bone marrow transplant (BMT) model (B6… (More)
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Highly Cited
1996
Highly Cited
1996
To elucidate the molecular mechanisms regulating the anti-inflammatory activities of recombinant human (rh)IL-11, the ability of… (More)
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Highly Cited
1994
Highly Cited
1994
Stromal cells of the bone marrow control the development of osteoclasts through the production of cytokines capable of promoting… (More)
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