Open Reading Frames

Known as: Coding Feature, ORF, Open Reading Frame 
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop… (More)
National Institutes of Health

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ChromosomesPPP1R17 geneStructural geneaspects of radiation effects
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Unassigned Reading Frames

Papers overview

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Review
2016
Review
2016
Islet biology, the CDKN2A/B locus and type 2 diabetes risk
Type 2 diabetes, fuelled by the obesity epidemic, is an escalating worldwide cause of personal hardship and public cost. Diabetes… (More)
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Highly Cited
2009
Highly Cited
2009
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans.
Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5' UTR that is out-of-frame with the main coding sequence… (More)
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Highly Cited
2008
Highly Cited
2008
Alternative Isoform Regulation in Human Tissue Transcriptomes
Through alternative processing of pre-messenger RNAs, individual mammalian genes often produce multiple mRNA and protein isoforms… (More)
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Highly Cited
2007
Highly Cited
2007
hORFeome v3.1: A resource of human open reading frames representing over 10,000 human genes
Complete sets of cloned protein-encoding open reading frames (ORFs), or ORFeomes, are essential tools for large-scale proteomics… (More)
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Highly Cited
2005
Highly Cited
2005
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed… (More)
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Highly Cited
2004
Highly Cited
2004
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
Stress-induced eukaryotic translation initiation factor 2 (eIF2) alpha phosphorylation paradoxically increases translation of the… (More)
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Highly Cited
2002
Highly Cited
2002
Transcriptional regulatory networks in Saccharomyces cerevisiae.
We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with… (More)
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Highly Cited
2000
Highly Cited
2000
The two largest chloroplast genome-encoded open reading frames of higher plants are essential genes.
The chloroplast genomes of most higher plants contain two giant open reading frames designated ycf1 and ycf2. In tobacco, ycf1… (More)
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Highly Cited
1997
Highly Cited
1997
Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization.
We have developed a new system of chromosomal mutagenesis in order to study the functions of uncharacterized open reading frames… (More)
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Highly Cited
1993
Highly Cited
1993
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14.
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by… (More)
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