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Open Reading Frames

Known as: Coding Feature, ORF, Open Reading Frame 
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2–3… Expand
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Highly Cited
2016
Highly Cited
2016
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA… Expand
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Highly Cited
2009
Highly Cited
2009
Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5′ UTR that is out-of-frame with the main coding sequence… Expand
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Highly Cited
2005
Highly Cited
2005
We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed… Expand
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Highly Cited
2004
Highly Cited
2004
Stress-induced eukaryotic translation initiation factor 2 (eIF2) α phosphorylation paradoxically increases translation of the… Expand
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Highly Cited
2003
Highly Cited
2003
The availability of complete genomic sequences and technologies that allow comprehensive analysis of global expression profiles… Expand
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Highly Cited
1998
Highly Cited
1998
Parkinson's disease is a common neurodegenerative disease with complex clinical features. Autosomal recessive juvenile… Expand
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Highly Cited
1993
Highly Cited
1993
The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification. We have used haplotype analysis of… Expand
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Highly Cited
1993
Highly Cited
1993
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by… Expand
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Highly Cited
1991
Highly Cited
1991
PROTEINS often differ in amino-acid sequence across species. This difference has evolved by the accumulation of neutral mutations… Expand
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