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Open Reading Frames

Known as: Coding Feature, ORF, Open Reading Frame 
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop… Expand
National Institutes of Health

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Related topics

6 relations
ChromosomesPPP1R17 geneStructural geneaspects of radiation effects
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Unassigned Reading Frames

Papers overview

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Review
2018
Review
2018
Long non-coding RNA: its evolutionary relics and biological implications in mammals: a review
The central dogma of gene expression propounds that DNA is transcribed to mRNA and finally gets translated into protein. Only 2–3… Expand
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Highly Cited
2016
Highly Cited
2016
Analysis of protein-coding genetic variation in 60,706 humans
Large-scale reference data sets of human genetic variation are critical for the medical and functional interpretation of DNA… Expand
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Highly Cited
2009
Highly Cited
2009
Upstream open reading frames cause widespread reduction of protein expression and are polymorphic among humans
Upstream ORFs (uORFs) are mRNA elements defined by a start codon in the 5′ UTR that is out-of-frame with the main coding sequence… Expand
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Highly Cited
2005
Highly Cited
2005
Conserved Seed Pairing, Often Flanked by Adenosines, Indicates that Thousands of Human Genes are MicroRNA Targets
We predict regulatory targets of vertebrate microRNAs (miRNAs) by identifying mRNAs with conserved complementarity to the seed… Expand
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Highly Cited
2004
Highly Cited
2004
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
Stress-induced eukaryotic translation initiation factor 2 (eIF2) α phosphorylation paradoxically increases translation of the… Expand
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Highly Cited
2003
Highly Cited
2003
Global analysis of protein expression in yeast
The availability of complete genomic sequences and technologies that allow comprehensive analysis of global expression profiles… Expand
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Highly Cited
1998
Highly Cited
1998
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
Parkinson's disease is a common neurodegenerative disease with complex clinical features. Autosomal recessive juvenile… Expand
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Highly Cited
1993
Highly Cited
1993
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes
The Huntington's disease (HD) gene has been mapped in 4p16.3 but has eluded identification. We have used haplotype analysis of… Expand
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Highly Cited
1993
Highly Cited
1993
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
lin-4 is essential for the normal temporal control of diverse postembryonic developmental events in C. elegans. lin-4 acts by… Expand
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Highly Cited
1991
Highly Cited
1991
Adaptive protein evolution at the Adh locus in Drosophila
PROTEINS often differ in amino-acid sequence across species. This difference has evolved by the accumulation of neutral mutations… Expand
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