Oligoribonucleotides

Known as: Oligoribonucleotides [Chemical/Ingredient] 
A group of ribonucleotides (up to 12) in which the phosphate residues of each ribonucleotide act as bridges in forming diester linkages between the… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Antiviral immunity is triggered by immunorecognition of viral nucleic acids. The cytosolic helicase RIG-I is a key sensor of… (More)
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Highly Cited
2008
Highly Cited
2008
The safe and effective delivery of RNA interference (RNAi) therapeutics remains an important challenge for clinical development… (More)
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Highly Cited
2006
Highly Cited
2006
Human adenocarcinomas commonly harbor mutations in the KRAS and MYC proto-oncogenes and the TP53 tumor suppressor gene. All three… (More)
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Highly Cited
2004
Highly Cited
2004
A large number of miRNAs have recently been discovered in plants and animals. Development of reverse genetic approaches that act… (More)
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Highly Cited
2001
Highly Cited
2001
Duchenne muscular dystrophy (DMD) is a severe muscle wasting disease arising from defects in the dystrophin gene, typically… (More)
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Highly Cited
1998
Highly Cited
1998
Deletions and point mutations in the gene encoding the cytoskeletal protein dystrophin and its isoforms cause either the severe… (More)
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Highly Cited
1995
Highly Cited
1995
The nuclease stability and melting temperatures (Tm) were compared for fully modified oligoribonucleotide sequences containing 2… (More)
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Highly Cited
1994
Highly Cited
1994
An RNA model system consisting of an oligomer binding to a 4-nt overhang at the 5' end of a hairpin stem provides thermodynamic… (More)
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Highly Cited
1994
Highly Cited
1994
We have devised a method to replace the cap structure of a mRNA with an oligoribonucleotide (r-oligo) to label the 5' end of… (More)
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Highly Cited
1987
Highly Cited
1987
A method is described to synthesize small RNAs of defined length and sequence using T7 RNA polymerase and templates of synthetic… (More)
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