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RNA–Amino Acid Binding: A Stereochemical Era for the Genetic Code
By combining crystallographic and NMR structural data for RNA-bound amino acids within riboswitches, aptamers, and RNPs, chemical principles governing specific RNA interaction with amino acids can be… Expand
Amino Acids as RNA Ligands: A Direct-RNA-Template Theory for the Code's Origin
- M. Yarus
- Medicine, Biology
- Journal of Molecular Evolution
- 1 July 1998
Abstract. Numerous RNA binding sites for specific amino acids are now known, coming predominantly from selection-amplification experiments. These sites are chemically discriminating despite being… Expand
Diversity of oligonucleotide functions.
SELEX is a technology for the identification of high affinity oligonucleotide ligands. Large libraries of random sequence single-stranded oligonucleotides, whether RNA or DNA, can be thought of… Expand
Rates of aminoacyl-tRNA selection at 29 sense codons in vivo.
We have placed aminoacyl-tRNA selection at individual codons in competition with a frameshift that is assumed to have a uniform rate. By assaying a reporter in the shifted frame, relative rates for… Expand
Origins of the genetic code: the escaped triplet theory.
There is very significant evidence that cognate codons and/or anticodons are unexpectedly frequent in RNA-binding sites for seven of eight biological amino acids that have been tested. This suggests… Expand
How Mitochondria Redefine the Code
Abstract. Annotated, complete DNA sequences are available for 213 mitochondrial genomes from 132 species. These provide an extensive sample of evolutionary adjustment of codon usage and meaning… Expand
Three small ribooligonucleotides with specific arginine sites.
Arginine-binding RNA motifs are important to protein-RNA interaction and perhaps also for Archean biochemistry. Selection-amplification was used to isolate three RNAs that are eluted by free arginine… Expand
Transfer RNA mutation and the malleability of the genetic code.
We propose that evolutionary reassignment of codons is facilitated by a translationally ambiguous intermediate. For example, recently discovered tRNA mutations that allow relatively efficient… Expand
Getting past the RNA world: the initial Darwinian ancestor.
- M. Yarus
- Biology, Medicine
- Cold Spring Harbor perspectives in biology
- 1 April 2011
A little-noted result of the confirmation of multiple premises of the RNA-world hypothesis is that we now know something about the dawn organisms that followed the origin of life, perhaps over 4… Expand
RNAs with dual specificity and dual RNAs with similar specificity.
The biological role of RNA is delimited by its possible reactions, which can be explored by selection. A comparison of selected RNAs that bind one ligand with those that bind two related ligands… Expand