• Publications
  • Influence
RNA–Amino Acid Binding: A Stereochemical Era for the Genetic Code
TLDR
There was likely a stereochemical era during evolution of the genetic code, relying on chemical interactions between amino acids and the tertiary structures of RNA binding sites, according to data from crystallographic and NMR structural data for RNA-bound amino acids within riboswitches, aptamers, and RNPs.
Amino Acids as RNA Ligands: A Direct-RNA-Template Theory for the Code's Origin
  • M. Yarus
  • Biology, Medicine
    Journal of Molecular Evolution
  • 1 July 1998
TLDR
An origins hypothesis which accommodates all the data, DRT (direct RNA templating), is formulated, and the implications for the origin of coded peptide synthesis are considered.
Rates of aminoacyl-tRNA selection at 29 sense codons in vivo.
TLDR
The rate of aminoacyl-tRNA selection by a YNC codon is always greater than the rate of the corresponding YNU codon even though in many YNC/U pairs both codons react with the same elongation factor Tu/GTP/aminoacyl -tRNA complex.
Diversity of oligonucleotide functions.
TLDR
The range of applications of this technology for new discovery extends from basic research reagents to the identification of novel diagnostic and therapeutic reagents, and examples of these applications are described.
Origins of the genetic code: the escaped triplet theory.
TLDR
It is shown that a substantial fraction of the genetic code has a stereochemical basis, the triplets having escaped from their original function in amino acid-binding sites to become modern codons and anticodons.
How Mitochondria Redefine the Code
TLDR
It is suggested that coding ambiguity, the extension of a tRNA's decoding capacity beyond its original set of codons, is the second event that promotes codon reassignment.
Three small ribooligonucleotides with specific arginine sites.
TLDR
Binding is highly specific for arginine, but all three motifs, like the self-splicing group I intron, also bind guanosine 5'-monophosphate, and one site is stereoselective, somewhat preferring D-arginine.
Transfer RNA mutation and the malleability of the genetic code.
TLDR
It is proposed that evolutionary reassignment of codons is facilitated by a translationally ambiguous intermediate, and characterized codon reassignments are strikingly non-random, and half can be immediately explained by unusual tRNA activities already demonstrated.
RNA-ligand chemistry: a testable source for the genetic code.
  • M. Yarus
  • Chemistry, Medicine
    RNA
  • 1 April 2000
TLDR
In the genetic code, triplet codons and amino acids can be shown to be related by chemical principles and at least some primordial coding assignments appear to have exploited triplets from amino acid binding sites as codons.
Getting past the RNA world: the initial Darwinian ancestor.
  • M. Yarus
  • Biology, Medicine
    Cold Spring Harbor perspectives in biology
  • 1 April 2011
TLDR
The confirmation of multiple premises of the RNA-world hypothesis means the authors now know something about the dawn organisms that followed the origin of life, perhaps over 4 billion years ago, and are in an improved position to reason about the biota just before RNA times.
...
1
2
3
4
5
...