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OSU 03012

Known as: 2-amino-N-(4-(5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide, AR-12 compound, OSU-03012 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PyrazolesSulfonamides

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Celecoxib derivative OSU-03012 inhibits the proliferation and activation of hepatic stellate cells by inducing cell senescence.
Liver fibrosis may lead to portal hypertension, liver failure or hepatocellular carcinoma, and predominantly results from the… 
2013
2013
OSU-03012, a non-cox inhibiting celecoxib derivative, induces apoptosis of human esophageal carcinoma cells through a p53/Bax/cytochrome c/caspase-9-dependent pathway
OSU-03012 is a celecoxib derivative devoid of cyclooxygenase-2 inhibitory activity. It was previously reported to inhibit the… 
2012
2012
OSU-03012 interacts with lapatinib to kill brain cancer cells
We have further defined mechanism(s) by which the drug OSU-03012 (OSU) kills brain cancer cells. OSU toxicity was enhanced by the… 
Highly Cited
2011
Highly Cited
2011
Identification, in vitro activity and mode of action of phosphoinositide-dependent-1 kinase inhibitors as antifungal molecules.
Although protein kinases have recently emerged as important drug targets, the anti-infective potential of protein kinase… 
2010
2010
OSU-03012 enhances Ad.7-induced GBM cell killing via ER stress and autophagy and by decreasing expression of mitochondrial protective proteins
The present studies focused on determining whether the autophagy-inducing drug OSU-03012 (AR-12) could enhance the toxicity of… 
2009
2009
Apoptosis and cancer : mutations within caspase genes
1 Department of Physiology, University of Manitoba, Winnipeg, Manitoba, Canada; 2 National Training Program in Allergy and Asthma… 
2008
2008
Retraction: Sensitizing Estrogen Receptor–negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor
Tamoxifen is a mainstay in the treatment of estrogen receptor (ER)–positive breast cancer patients. Although the efficacy of… 
2007
2007
The Phosphoinositide-Dependent Kinase-1 Inhibitor 2-Amino-N-[4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl]-acetamide (OSU-03012) Prevents Y-Box Binding Protein-1 from Inducing…
The epidermal growth factor receptor (EGFR) is integral to basal-like and human epidermal growth factor receptor-2 (Her-2… 
Review
2007
Review
2007
OSU-03012 stimulates PERK-dependent increases in HSP 70 expression , attenuating its lethal actions in transformed cells
  • 2007
  • Corpus ID: 26352273
We have further defined mechanism(s) by which OSU-03012 (OSU), a derivative of the COX2 inhibitor Celecoxib but lacking COX2… 
2005
2005
A structurally optimized celecoxib derivative inhibits human pancreatic cancer cell growth
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