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ORC6 gene

Known as: origin recognition complex subunit 6, ORC6L Gene, ORC6-LIKE 
This gene is involved in DNA binding, initiation of DNA replication and transcriptional silencing.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Viability ProcessDNA ReplicationORC6L protein, humanOrigin Recognition Complex, Subunit 6

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
Defective replication initiation results in locus specific chromosome breakage and a ribosomal RNA deficiency in yeast
A form of dwarfism known as Meier-Gorlin syndrome (MGS) is caused by recessive mutations in one of six different genes (ORC1… 
2013
2013
The cellular impact of diminished DNA origin licensing capacity and its potential therapeutic exploitation
Genomic instability underlies various diseases including cancer. The maintenance of genomic stability requires accurate… 
2013
2013
DNA Damage and Repair DiminishedOrigin-LicensingCapacity Speci fi cally Sensitizes Tumor Cells to Replication Stress
Previous studies have shown that dormant licensed replication origins can be exploited to enhance recovery from replication… 
2011
2011
CDK prevents Mcm 2 – 7 helicase loading by inhibiting Cdt 1 interaction with Orc 6
In Saccharomyces cerevisiae cells, B-type cyclin-dependent kinases (CDKs) target two origin recognition complex (ORC) subunits… 
2010
2010
Gene expression analysis on a photodiode array-based bioluminescence analyzer by using sensitivity-improved SRPP.
Most methods used for gene expression analysis are based on dye-labeling, which requires costly instruments. Recently a dye-free… 
2008
2008
Functional Characterization of the Origin Recognition Complex (ORC) in S. cerevisiae
The origin recognition complex (Orc1-6) plays a fundamental role in the initiation of DNA replication by binding replication… 
2008
2008
Characterization of Orc6 function following pre-replicative complex assembly in Saccharomyces cerevisiae
Pre-replicative complex (pre-RC) components the origin recognition complex (ORC), Cdc6, and Cdt1, play key roles in the… 
2007
2007
Roles of the CDK phosphorylation sites of yeast Cdc6 in chromatin binding and rereplication.
The Saccharomyces cerevisiae Cdc6 protein is crucial for DNA replication. In the absence of cyclin-dependent kinase (CDK… 
2006
2006
MBD4 and SEI1 as new prognostic markers in colorectal cancer patients receiving adjuvant 5-fluorouracil.
20085 Background: Previous studies from our laboratory have identified a number of marker genes associated with chemosensitivity… 
Highly Cited
2003
Highly Cited
2003
Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells.
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