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ORC6 gene

Known as: origin recognition complex subunit 6, ORC6L Gene, ORC6-LIKE 
This gene is involved in DNA binding, initiation of DNA replication and transcriptional silencing.
National Institutes of Health

Related topics

Related topics

6 relations
Cell Viability ProcessDNA ReplicationORC6L protein, humanOrigin Recognition Complex, Subunit 6

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Mutations in CDC45, Encoding an Essential Component of the Pre-initiation Complex, Cause Meier-Gorlin Syndrome and Craniosynostosis.
2013
2013
A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation
In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome… 
Highly Cited
2011
Highly Cited
2011
CDK prevents Mcm2-7 helicase loading by inhibiting Cdt1 interaction with Orc6.
In Saccharomyces cerevisiae cells, B-type cyclin-dependent kinases (CDKs) target two origin recognition complex (ORC) subunits… 
Highly Cited
2007
Highly Cited
2007
Orc6 is required for dynamic recruitment of Cdt1 during repeated Mcm2-7 loading.
The origin recognition complex (ORC) nucleates DNA replication initiation in eukaryotic cells. This six-protein complex binds… 
Highly Cited
2006
Highly Cited
2006
Contribution of the BOP1 gene, located on 8q24, to colorectal tumorigenesis
The most common form of genomic instability observed in colorectal cancer is chromosomal instability (CIN), whose molecular bases… 
Highly Cited
2006
Highly Cited
2006
An essential role for Orc6 in DNA replication through maintenance of pre‐replicative complexes
The heterohexameric origin recognition complex (ORC) acts as a scaffold for the G1 phase assembly of pre‐replicative complexes… 
Highly Cited
2003
Highly Cited
2003
A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity
Coordination between separate pathways may be facilitated by the requirements for common protein factors, a finding congruent… 
Highly Cited
2002
Highly Cited
2002
Orc6 Involved in DNA Replication, Chromosome Segregation, and Cytokinesis
Origin recognition complex (ORC) proteins serve as a landing pad for the assembly of a multiprotein prereplicative complex, which… 
Highly Cited
2001
Highly Cited
2001
Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins
BackgroundIn order to ensure precise chromosome duplication, eukaryotes "license" their replication origins during late mitosis… 
Highly Cited
2000
Highly Cited
2000
Identification and Characterization of the Human ORC6 Homolog*
A new protein was cloned and identified as the sixth member of the human origin recognition complex (ORC). The newly identified… 
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