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OPN-305

Known as: Anti-TLR2 Monoclonal Antibody OPN-305 
A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2), with potential anti-inflammatory and… Expand
National Institutes of Health

Related topics

Related topics

2 relations

Broader (1)

Monoclonal Antibodies
antigen binding

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A Clinical Study of Tomaralimab (OPN-305), a Toll-like Receptor 2 (TLR-2) Antibody, in Heavily Pre-Treated Transfusion Dependent Patients with Lower Risk Myelodysplastic Syndromes (MDS) That Have…
INTRODUCTION: Innate immune sensors such as TLR2 are consistently overexpressed in bone marrow CD34+ cells from low risk MDS… Expand
2018
2018
Associação entre os polimorfismos TLR2, TLR4, IL1B e TNFA e risco de infecção por Mycobacterium Tuberculosis e desenvolvimento da infecção ativa em contatos de casos de tuberculose do Brasil
 
Review
2018
Review
2018
TLRs/NLRs: Shaping the landscape of host immunity
ABSTRACT Innate immune system provides the first line of defense against pathogenic organisms. It has a varied and large… Expand
2016
2016
Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study
BackgroundGenetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem… Expand
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2016
2016
A Clinical Study of OPN-305, a Toll-like Receptor 2 (TLR-2) Antibody, in Patients with Lower Risk Myelodysplastic Syndromes (MDS) That Have Received Prior Hypomethylating Agent (HMA) Therapy
INTRODUCTION: Alterations of innate immune signaling, including overexpression of TLR2, are common in MDS. Signaling mediated by… Expand
2016
2016
Do Nutrients Counteract the Acute Cardiovascular Effects of Air Particles? The Role of Immuno-Epigenetics in Observational and Intervention Studies
Background: Fine particulate matter (PM2.5) pollution is a major risk factor for cardiovascular diseases. Identifying modifiable… Expand
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Highly Cited
2013
Highly Cited
2013
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody
Upregulation of Toll‐like receptor 2 (TLR2) plays a critical role in inflammation associated with ischemia/reperfusion–induced… Expand
2013
2013
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2
OPN-305 is a humanized IgG4 monoclonal antibody against Tolllike receptor (TLR)2 being developed by Opsona Therapeutics. It is… Expand
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Highly Cited
2012
Highly Cited
2012
Treatment With OPN-305, a Humanized Anti–Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs
Background— Toll-like receptor (TLR)-2 is an important mediator of innate immunity and ischemia/reperfusion-induced cardiac… Expand
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2012
2012
TLR9 −1237 T/C and TLR2 −194 to −174 del polymorphisms and the risk of Parkinson’s disease in the Greek population: a pilot study
Toll-like receptors (TLRs) are important mediators of inflammatory responses by recognition of many pathogen-related molecules… Expand
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