OPN-305

Known as: Anti-TLR2 Monoclonal Antibody OPN-305 
A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2), with potential anti-inflammatory and… Expand
National Institutes of Health

Related topics

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2 relations

Broader (1)

Monoclonal Antibodies
antigen binding

Papers overview

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2018
2018
Associação entre os polimorfismos TLR2, TLR4, IL1B e TNFA e risco de infecção por Mycobacterium Tuberculosis e desenvolvimento da infecção ativa em contatos de casos de tuberculose do Brasil
 
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2018
2018
A Clinical Study of Tomaralimab (OPN-305), a Toll-like Receptor 2 (TLR-2) Antibody, in Heavily Pre-Treated Transfusion Dependent Patients with Lower Risk Myelodysplastic Syndromes (MDS) That Have…
INTRODUCTION: Innate immune sensors such as TLR2 are consistently overexpressed in bone marrow CD34+ cells from low risk MDS… Expand
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Review
2018
Review
2018
TLRs/NLRs: Shaping the landscape of host immunity.
  • International reviews of immunology
  • 2018
Innate immune system provides the first line of defense against pathogenic organisms. It has a varied and large collection of… Expand
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2016
2016
Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study
BackgroundGenetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem… Expand
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2016
2016
Do Nutrients Counteract the Acute Cardiovascular Effects of Air Particles? The Role of Immuno-Epigenetics in Observational and Intervention Studies
Background: Fine particulate matter (PM2.5) pollution is a major risk factor for cardiovascular diseases. Identifying modifiable… Expand
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2013
2013
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody
Upregulation of Toll-like receptor 2 (TLR2) plays a critical role in inflammation associated with ischemia/reperfusion-induced… Expand
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2013
2013
Randomized , Double-Blind , Placebo-Controlled , Dose-Escalating Phase I , Healthy Subjects Study of Intravenous OPN-305 , a Humanized Anti-TLR 2 Antibody
OPN-305 is a humanized IgG4 monoclonal antibody against Tolllike receptor (TLR)2 being developed by Opsona Therapeutics. It is… Expand
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2013
2013
Association of TLR2 and TLR4 Polymorphisms with Risk of Cancer: A Meta-Analysis
BACKGROUNDS The activation of Toll-like receptors (TLRs) may be an important event in the immune evasion of tumor cell. Recently… Expand
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2012
2012
Treatment with OPN-305, a humanized anti-Toll-Like receptor-2 antibody, reduces myocardial ischemia/reperfusion injury in pigs.
BACKGROUND Toll-like receptor (TLR)-2 is an important mediator of innate immunity and ischemia/reperfusion-induced cardiac injury… Expand
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2012
2012
TLR9 −1237 T/C and TLR2 −194 to −174 del polymorphisms and the risk of Parkinson’s disease in the Greek population: a pilot study
Toll-like receptors (TLRs) are important mediators of inflammatory responses by recognition of many pathogen-related molecules… Expand
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