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OPN-305

Known as: Anti-TLR2 Monoclonal Antibody OPN-305 
A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2), with potential anti-inflammatory and… 
National Institutes of Health

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Broader (1)

Monoclonal Antibodies
antigen binding

Papers overview

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2018
2018
Associação entre os polimorfismos TLR2, TLR4, IL1B e TNFA e risco de infecção por Mycobacterium Tuberculosis e desenvolvimento da infecção ativa em contatos de casos de tuberculose do Brasil
2018
2018
Dengue virus NS 1 protein activates immune cells via TLR 4 but not TLR 2 or TLR 6
The secreted hexameric form of the dengue virus non-structural protein 1 (NS1) has recently been shown to elicit inflammatory… 
2017
2017
Gene Polymorphisms of TLR2 and TLR3 in HBV Clearance and HBV-Related Hepatocellular Carcinoma in a Chinese Male Population
Background The Toll-like receptor plays an essential role in controlling immunity and inflammation. This study was to investigate… 
2016
2016
A Clinical Study of OPN-305, a Toll-like Receptor 2 (TLR-2) Antibody, in Patients with Lower Risk Myelodysplastic Syndromes (MDS) That Have Received Prior Hypomethylating Agent (HMA) Therapy
INTRODUCTION: Alterations of innate immune signaling, including overexpression of TLR2, are common in MDS. Signaling mediated by… 
2016
2016
Association of toll-like receptor 2 ∆22 and risk for gastric cancer considering main effects and interactions with smoking: a matched case-control study from Mizoram, India
Toll-like receptors (TLRs) are evolutionary conserved cell surface receptors of the innate immune system. Smoking has significant… 
2015
2015
Toll‐like receptor 2 subfamily gene polymorphisms are associated with Bacillus Calmette‐Guérin osteitis following newborn vaccination
Toll‐like receptor (TLR) 1, 2, 6 and 10, the TLR2 subfamily, are known to be associated with immunity against tuberculosis. We… 
2014
2014
O-224 Toll-like Receptors Genotype Polymorphism In Egyptian Children With Chronic Viral Hepatitis C
Background Toll-like receptors (TLRs) are important molecules for both innate and adaptive immune responses. The prevalence of… 
2013
2013
TLR9 −1237 T/C and TLR2 −194 to −174 del polymorphisms and the risk of Parkinson’s disease in the Greek population: a pilot study
Toll-like receptors (TLRs) are important mediators of inflammatory responses by recognition of many pathogen-related molecules… 
2013
2013
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2
OPN-305 is a humanized IgG4 monoclonal antibody against Tolllike receptor (TLR)2 being developed by Opsona Therapeutics. It is… 
2009
2009
Effects of CD14, TLR2, TLR4, LPB, and IL‐6 Gene Polymorphisms on Chlamydia pneumoniae Growth in Human Macrophages In Vitro
Chlamydia pneumoniae is an obligate intracellular gram‐negative bacterium, which causes respiratory infections in humans. It can… 
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