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OPN-305
Known as:
Anti-TLR2 Monoclonal Antibody OPN-305
A humanized immunoglobulin (Ig) G4 monoclonal antibody directed against toll-like receptor type 2 (TLR2), with potential anti-inflammatory and…
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National Institutes of Health
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Related topics
Related topics
2 relations
Broader (1)
Monoclonal Antibodies
antigen binding
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
A Clinical Study of Tomaralimab (OPN-305), a Toll-like Receptor 2 (TLR-2) Antibody, in Heavily Pre-Treated Transfusion Dependent Patients with Lower Risk Myelodysplastic Syndromes (MDS) That Have…
G. Garcia-Manero
,
E. Jabbour
,
+15 authors
H. M. Kantarjian
2018
Corpus ID: 59351964
INTRODUCTION: Innate immune sensors such as TLR2 are consistently overexpressed in bone marrow CD34+ cells from low risk MDS…
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2018
2018
Associação entre os polimorfismos TLR2, TLR4, IL1B e TNFA e risco de infecção por Mycobacterium Tuberculosis e desenvolvimento da infecção ativa em contatos de casos de tuberculose do Brasil
Juan Manuel Cubillos-Angulus
,
M. B. A. Gutierrez
,
+13 authors
Ba Brasil. Escola Bahianade Medicina e Saúde Pública. Salvado
2018
Corpus ID: 91891092
Review
2018
Review
2018
TLRs/NLRs: Shaping the landscape of host immunity
Komal Dolasia
,
M. K. Bisht
,
Gourango Pradhan
,
Atul Udgata
,
S. Mukhopadhyay
International reviews of immunology
2018
Corpus ID: 205590122
ABSTRACT Innate immune system provides the first line of defense against pathogenic organisms. It has a varied and large…
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2016
2016
Toxoplasma gondii exposure may modulate the influence of TLR2 genetic variation on bipolar disorder: a gene–environment interaction study
J. Oliveira
,
R. Kazma
,
+11 authors
R. Tamouza
International Journal of Bipolar Disorders
2016
Corpus ID: 15579235
BackgroundGenetic vulnerability to environmental stressors is yet to be clarified in bipolar disorder (BD), a complex multisystem…
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2016
2016
A Clinical Study of OPN-305, a Toll-like Receptor 2 (TLR-2) Antibody, in Patients with Lower Risk Myelodysplastic Syndromes (MDS) That Have Received Prior Hypomethylating Agent (HMA) Therapy
G. Garcia-Manero
,
G. Montalban-Bravo
,
+13 authors
M. Reilly
2016
Corpus ID: 208433148
INTRODUCTION: Alterations of innate immune signaling, including overexpression of TLR2, are common in MDS. Signaling mediated by…
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2016
2016
Do Nutrients Counteract the Acute Cardiovascular Effects of Air Particles? The Role of Immuno-Epigenetics in Observational and Intervention Studies
J. Zhong
2016
Corpus ID: 77963331
Background: Fine particulate matter (PM2.5) pollution is a major risk factor for cardiovascular diseases. Identifying modifiable…
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Highly Cited
2013
Highly Cited
2013
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2 Antibody
M. Reilly
,
R. Miller
,
+10 authors
J. van de Wetering de Rooij
Clinical pharmacology and therapeutics
2013
Corpus ID: 17504889
Upregulation of Toll‐like receptor 2 (TLR2) plays a critical role in inflammation associated with ischemia/reperfusion–induced…
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2013
2013
Randomized, Double-Blind, Placebo-Controlled, Dose-Escalating Phase I, Healthy Subjects Study of Intravenous OPN-305, a Humanized Anti-TLR2
M. Reilly
,
R. Miller
,
+10 authors
J. V. Rooij
2013
Corpus ID: 54804828
OPN-305 is a humanized IgG4 monoclonal antibody against Tolllike receptor (TLR)2 being developed by Opsona Therapeutics. It is…
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Highly Cited
2012
Highly Cited
2012
Treatment With OPN-305, a Humanized Anti–Toll-Like Receptor-2 Antibody, Reduces Myocardial Ischemia/Reperfusion Injury in Pigs
F. Arslan
,
J. Houtgraaf
,
+11 authors
D. D. de Kleijn
Circulation. Cardiovascular interventions
2012
Corpus ID: 9557927
Background— Toll-like receptor (TLR)-2 is an important mediator of innate immunity and ischemia/reperfusion-induced cardiac…
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2012
2012
TLR9 −1237 T/C and TLR2 −194 to −174 del polymorphisms and the risk of Parkinson’s disease in the Greek population: a pilot study
K. Kalinderi
,
S. Bostantjopoulou
,
Z. Katsarou
,
L. Fidani
Neurological Sciences
2012
Corpus ID: 19680708
Toll-like receptors (TLRs) are important mediators of inflammatory responses by recognition of many pathogen-related molecules…
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