Skip to search formSkip to main contentSkip to account menu

OPC 4392

Known as: 2(1H)-Quinolinone, 7-(3-(4-(2,3-dimethylphenyl)-1-piperazinyl)propoxy)-, OPC-4392 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

PiperazinesQuinolones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models.
While dopamine D2 receptor partial agonists (PAs) have been long considered for treating schizophrenia, only one, aripiprazole… 
Highly Cited
2008
Highly Cited
2008
Characterization of aripiprazole partial agonist activity at human dopamine D3 receptors.
2007
2007
Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling
Highly Cited
2005
Highly Cited
2005
Aripiprazole's low intrinsic activities at human dopamine D2L and D2S receptors render it a unique antipsychotic.
2005
2005
Neuroendocrine profile of SDZ HDC-912 and OPC-4392, two new atypical antipsychotic drugs, in schizophrenic patients
The aim of this study was to evaluate the effect on the activity of the hypothalamic-pituitary dopaminergic system of two new… 
1996
1996
Partial agonistic effects of OPC-14597, a potential antipsychotic agent, on yawning behavior in rats
Highly Cited
1995
Highly Cited
1995
7-(4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyloxy)-3,4-dihydro-2(1H)-quinolinone (OPC-14597), a new putative antipsychotic drug with both presynaptic dopamine autoreceptor agonistic activity and…
1988
1988
The Effect of OPC-4392, a Partial Dopamine Receptor Agonist on Negative Symptoms: Results of an Open Study
OPC4392 (7 -3-[4-(2,3-dimethylphenyl)piperazinyl]-propoxy-2(1 H)-quinolinone) belongs to a new dass of compounds aeting as… 
1988
1988
Studies on 2(1H)-quinolinone derivatives as neuroleptic agents I. Synthesis and biological activities of (4-phenyl-1-piperazinyl)-propoxy-2(1H)-quinolinone derivatives.
With the aim of developing a novel neuroleptic drug, a series of ω-(4-phenyl-1-piperazinyl)-alkoxy-2 (1H)-quinolinone derivatives… 
1988
1988
7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)