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OPC 4392

Known as: 2(1H)-Quinolinone, 7-(3-(4-(2,3-dimethylphenyl)-1-piperazinyl)propoxy)-, OPC-4392 
National Institutes of Health

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2 relations

Broader (2)

PiperazinesQuinolones

Papers overview

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2011
2011
Partial agonists in schizophrenia--why some work and others do not: insights from preclinical animal models.
While dopamine D2 receptor partial agonists (PAs) have been long considered for treating schizophrenia, only one, aripiprazole… 
1997
1997
Unique Pharmacological Profile of a Novel Antipsychotic Drug, Aripiprazole (OPC-14597)
Aripiprazole (OPC-14597) is a novel antipsychotic agent with an unusual pharmacological profile that is atypical of compounds… 
1996
1996
Partial agonistic effects of OPC-14597, a potential antipsychotic agent, on yawning behavior in rats
1990
1990
Interactions of 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)-propoxy]-2(lH)-quinolinone (OPC-4392) with 3H-Spiperone and 3H-SCH 23390 Binding in Rat Striatum: Effects of Lesions
Abstract7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(lH)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor… 
1990
1990
D-2 receptor-mediated inhibition by a substituted quinolinone derivative, 7-[3-(4-(2,3-dimethylphenyl)piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), of dopaminergic neurons in the ventral…
1988
1988
The Effect of OPC-4392, a Partial Dopamine Receptor Agonist on Negative Symptoms: Results of an Open Study
OPC4392 (7 -3-[4-(2,3-dimethylphenyl)piperazinyl]-propoxy-2(1 H)-quinolinone) belongs to a new dass of compounds aeting as… 
1988
1988
7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist.
1988
1988
Phase 1 study of a new antipsychotic drug, OPC-4392.
1. A phase I study of OPC-4392 (OPC), a quinolinone derivative recently developed in Japan and recognized to have an agonistic… 
1988
1988
Phase 1 study of a new antipsychotic drug, OPC-4392
1988
1988
Presynaptic inhibition of excitatory input from the substantia nigra to caudate nucleus neurons by a substituted quinolinone derivative, 7-[3-(4-(2,3-dimethylphenyl)piperazinyl)propoxy]-2(1H…
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