In vivo biogenic amine efflux in medial prefiontal cortex with imipramine, fluoxetine, and fluvoxamine
The data suggest that the SSRIs are not entirely selective for serotonin in vivo, as compared with the standard tricyclic antidepressant imipramine and the two selective serotonin reuptake inhibitors, fluoxetine and fluvoxamine.
In vivo effects of aripiprazole on cortical and striatal dopaminergic and serotonergic function.
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor.
Functional Studies of Specific Imidazoline‐2 Receptor Ligands
Interaction of the novel antipsychotic aripiprazole with 5-HT1A and 5-HT2A receptors: functional receptor-binding and in vivo electrophysiological studies
Results support a partial agonist activity for aripiprazole at 5-HT1A receptors in vitro and in vivo, and suggest important interactions with other 4-HT-receptor subtypes and this receptor activity profile may contribute to the antipsychotic activity of aripine in humans.
Dopamine D2 receptor partial agonists display differential or contrasting characteristics in membrane and cell-based assays of dopamine D2 receptor signaling
The antipsychotic aripiprazole is a potent, partial agonist at the human 5-HT1A receptor
Previous stress increases in vivo biogenic amine response to swim stress
In vivo microdialysis was used to determine biogenic amines in medial prefrontal cortex of rats exposed to eight minutes of swim stress, and a robust increase was observed in all 3 neurotransmitters measured.
Discriminative stimulus properties of toluene in the mouse.
Discriminative stimulus produced by the imidazoline I2 site ligand, 2 -BFI
- S. Jordan, H. Jackson, D. Nutt, S. Handley
- Chemistry, BiologyJournal of psychopharmacology
- 1 July 1996
The observed pattern of drug substitution is consistent with the previously reported ability of 2-BFI to decrease MAO activity and thus increase extracellular monoamines.