ONYX015

Known as: CI-1042, ONYX-015, CI1042 
An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released… (More)
National Institutes of Health

Papers overview

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Review
2007
Review
2007
Ten years ago Frank McCormick proposed dl1520 as an oncolytic adenovirus. Although great as an inspiration for better oncolytic… (More)
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Review
2007
Review
2007
The current field of oncolytic virus development has evolved from, and been educated by, the route adenoviruses have taken to… (More)
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2005
2005
Armed oncolytic adenoviruses represent an appealing tumor treatment approach, as they can attack tumors at multiple levels. In… (More)
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Highly Cited
2001
Highly Cited
2001
Recent research has indicated that viruses specifically infecting tumor cells could be used as an alternative therapeutic… (More)
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Highly Cited
2000
Highly Cited
2000
ONYX-015 is an adenovirus with the E1B 55-kDa gene deleted, engineered to selectively replicate in and lyse p53-deficient cancer… (More)
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Highly Cited
1999
Highly Cited
1999
The adenovirus type 5 mutant dl1520 was engineered previously to be completely defective for E1B-55K functions. Recently, this… (More)
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Highly Cited
1999
Highly Cited
1999
Replication-incompetent viral vectors are being developed for the gene therapy of cancer. Although some of these may eventually… (More)
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1999
1999
An E1B 55-kDa gene-defective adenovirus (Adv), ONYX-015, has been reported to be a highly useful replication-competent Adv that… (More)
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Highly Cited
1998
Highly Cited
1998
Two obstacles limiting the efficacy of nearly all cancer gene therapy trials are low gene transduction efficiencies and the lack… (More)
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Highly Cited
1997
Highly Cited
1997
The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and inactivates the p53 gene, which is mutated in half… (More)
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