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ONYX015

Known as: CI-1042, ONYX-015, CI1042 
An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Antineoplastic AgentsViral Vaccines
Positive Regulation of Cytolytic Process

Narrower (1)

dl1520

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2007
2007
Lovastatin enhances the replication of the oncolytic adenovirus dl1520 and its antineoplastic activity against anaplastic thyroid carcinoma cells.
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors and shows morphological features of a highly… 
2006
2006
p53 promotes adenoviral replication and increases late viral gene expression
The tumor suppressor protein, p53, plays a critical role in viro-oncology. However, the role of p53 in adenoviral replication is… 
2005
2005
Potent antitumor efficacy of an E1B 55kDa‐deficient adenovirus carrying murine endostatin in hepatocellular carcinoma
Data from clinical trails have shown that the antitumoral effect of ONYX‐015, an E1B 55kDa‐deficient adenovirus, as monotherapy… 
Review
2005
Review
2005
Targeting gene-virotherapy of cancer.
Our purpose is to completely elimination of xenograft tumor in animal tumor model in order to work out a protocal for the cure of… 
2004
2004
The dl1520 Virus Is Found Preferentially in Tumor Tissue after Direct Intratumoral Injection in Oral Carcinoma
Purpose: dl1520 (also known as Onyx-015) is an E1B-deleted adenovirus designed to selectively lyse p53-deficient cancer cells… 
2003
2003
ONYX-015 enhances radiation-induced death of human anaplastic thyroid carcinoma cells.
ONYX-015 is a genetically modified adenovirus with a deletion of the E1B early gene and therefore is designed to replicate… 
Review
2002
Review
2002
Replication-selective viruses for cancer therapy
Abstract. Advances in our understanding of the molecular basis of cancer and the availability of technology to genetically… 
Highly Cited
2002
Highly Cited
2002
ONYX-015, an E1B gene-defective adenovirus, induces cell death in human anaplastic thyroid carcinoma cell lines.
Being one of the most lethal human neoplasms and refractory to such conventional treatment as chemo- and radiotherapy, anaplastic… 
Highly Cited
2001
Highly Cited
2001
Gene delivery from the E3 region of replicating human adenovirus: evaluation of the 6.7 K/gp19 K region
The use of genetically engineered, replication-selective viruses to treat cancer is being realized with viruses such as ONYX-015… 
Highly Cited
1999
Highly Cited
1999
Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas.
An E1B 55-kDa gene-defective adenovirus (Adv), ONYX-015, has been reported to be a highly useful replication-competent Adv that… 
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