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ONYX015

Known as: CI-1042, ONYX-015, CI1042 
An E1B-55kDa-deleted adenovirus that is able to selectively replicate in and lyse TP53-deficient human tumor cells. After tumor cell lysis, released… Expand
National Institutes of Health

Papers overview

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Highly Cited
2004
Highly Cited
2004
ONYX-015 is an oncolytic virus untested as a treatment for malignant glioma. The NABTT CNS Consortium conducted a dose-escalation… Expand
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Highly Cited
2003
Highly Cited
2003
PURPOSE Localized pancreatic carcinoma is rarely resectable and is resistant to conventional therapies. ONYX-015 (dl1520) is an… Expand
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Highly Cited
2001
Highly Cited
2001
PURPOSE To determine the safety, humoral immune response replication, and activity of multiple intratumoral injections of ONYX… Expand
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Highly Cited
2000
Highly Cited
2000
ONYX-015 is an adenovirus with the E1B 55-kDa gene deleted, engineered to selectively replicate in and lyse p53-deficient cancer… Expand
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Highly Cited
2000
Highly Cited
2000
The adenovirus mutant dl1520 (ONYX-015) does not express the E1B-55K protein that binds and inactivates p53. This virus… Expand
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Highly Cited
2000
Highly Cited
2000
  • I. Ganly, D. Kirn, +9 authors S. Kaye
  • Clinical cancer research : an official journal of…
  • 2000
  • Corpus ID: 5737510
An E1B 55 kDa gene-deleted adenovirus, Onyx-015, which reportedly selectively replicates in and lyses p53-deficient cells, was… Expand
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Highly Cited
2000
Highly Cited
2000
The E1B-deleted, replication-competent ONYX-015 (dl1520) adenovirus was originally described as being able to selectively kill… Expand
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Highly Cited
1998
Highly Cited
1998
ABSTRACT The 55-kDa E1B protein of adenovirus, which binds to and inactivates the tumor suppressor protein p53, is not expressed… Expand
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Highly Cited
1998
Highly Cited
1998
Two obstacles limiting the efficacy of nearly all cancer gene therapy trials are low gene transduction efficiencies and the lack… Expand
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Highly Cited
1997
Highly Cited
1997
The 55-kilodalton (kDa) protein from the E1B-region of adenovirus binds to and inactivates the p53 gene, which is mutated in half… Expand
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