dl1520
National Institutes of Health
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Anaplastic thyroid carcinoma (ATC) is one of the most aggressive solid tumors and shows morphological features of a highly…
In this study we have made novel observations with regards to potentiation of the tumoricidal activity of the oncolytic…
In 2003 we published two articles in Clinical Cancer Research describing the results of our clinical studies with ONYX-015 in…
New clinical trial data on the use of the ONYX-015 adenovirus as a chemosensitizing agent indicate that further study of this…
Purpose: dl1520 (also known as Onyx-015) is an E1B-deleted adenovirus designed to selectively lyse p53-deficient cancer cells…
Viruses that replicate selectively in cancer cells constitute an exciting new class of anticancer agent. The conditionally…
ONYX-015 (dl1520) is an E1B 55-kilodalton protein-deficient replicating adenovirus that is currently in clinical trials as an…
Background and aims: E1B-deleted virus dl1520 (ONYX-015) has been previously used in clinical trials mainly for treatment of head…
It has been suggested the E1B 55 kDa mutant adenovirus dl1520 can selectively killp53-deficient human tumor cells. In this study…
An E1B gene-attenuated adenovirus ( dl1520) has been proposed to have a selective cytolytic activity in cancer cells with a…