Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas.

@article{Shinoura1999HighlyAC,
  title={Highly augmented cytopathic effect of a fiber-mutant E1B-defective adenovirus for gene therapy of gliomas.},
  author={Nobusada Shinoura and Yoko Yoshida and Rikiya Tsunoda and Makoto Ohashi and Wei Zhang and Akio Asai and Takaaki Kirino and Hirofumi Hamada},
  journal={Cancer research},
  year={1999},
  volume={59 14},
  pages={3411-6}
}
An E1B 55-kDa gene-defective adenovirus (Adv), ONYX-015, has been reported to be a highly useful replication-competent Adv that shows cytopathic effect for cancers with an abnormal p53 gene, without damaging normal tissues. In this study, we combined this Adv (Adv-E1AdB) with a fiber mutation, F/K20, which has a stretch of 20 lysine residues added at the COOH-terminus of the fiber and shows high transduction efficiency to gliomas. In U-373 MG glioma cells, the transduction efficiency of Adv-F… CONTINUE READING

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An adenovirus mutant 3415 GENE THERAPY BY A FIBER-MUTANT E1B-DEFECTIVE

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