ONO 8711

Known as: 6-((2S,3S)-3-(4-chloro-2-methylphenysulfonylaminomethyl)-bicyclo(2.2.2)octan-2-yl)-5Z-hexenoic acid, ONO-8711, ONO8711 
 
National Institutes of Health

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2 relations

Broader (2)

Bridged Bicyclo CompoundsCaproates

Papers overview

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Highly Cited
2006
Highly Cited
2006
Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells.
Recent evidence indicates that cyclooxygenase-2 (COX-2) and epidermal growth factor receptor (EGFR) are involved in… Expand
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2006
2006
A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
We previously reported that certain cyclooxygenase (COX) inhibitors could inhibit chemically induced tongue carcinogenesis. In… Expand
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Highly Cited
2005
Highly Cited
2005
Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt.
Cyclooxygenase-2 (COX-2)-mediated prostaglandin synthesis has recently been implicated in human cholangiocarcinogenesis. This… Expand
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2004
2004
Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713.
This study investigated the effects and selectivity of ONO-AE-248, ONO-DI-004, ONO-8711 and ONO-8713 on EP1 and EP3 receptors in… Expand
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2001
2001
Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development.
Levels of prostaglandin E(2) (PGE(2)) in human and rodent breast cancers are higher than surrounding normal tissues. PGE(2… Expand
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2001
2001
The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP(1), ONO-8711, in a rat model of postoperative pain.
UNLABELLED Mechanically evoked pain, also known as incident pain, induced by coughing or deep breathing after surgery leads to… Expand
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2001
2001
Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo.
Studies support a role for glucagon-like peptide 1 (GLP-1) as a potential treatment for diabetes. However, since GLP-1 is rapidly… Expand
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2001
2001
A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction.
UNLABELLED Chronic constriction injury (CCI) of the sciatic nerve in rats induces persistent mechanical hyperalgesia and… Expand
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2000
2000
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.
We previously reported that prostaglandin E(2) contributes to colon carcinogenesis through its binding to the prostaglandin E… Expand
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Highly Cited
1999
Highly Cited
1999
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Although the cyclooxygenase pathway of the arachidonic acid cascade has been suggested to play an important role in colon… Expand
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