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ONO 8711

Known as: 6-((2S,3S)-3-(4-chloro-2-methylphenysulfonylaminomethyl)-bicyclo(2.2.2)octan-2-yl)-5Z-hexenoic acid, ONO-8711, ONO8711 
 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

Bridged Bicyclo CompoundsCaproates

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Effect of intrathecal administration of E‐series prostaglandin 1 receptor antagonist in a cyclophosphamide‐induced cystitis rat model
Objectives:  To investigate the effect of intrathecal administration of E‐series prostaglandin 1 antagonist in cyclophosphamide… Expand
2007
2007
A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis.
We previously reported that certain cyclooxygenase (COX) inhibitors could inhibit chemically induced tongue carcinogenesis. In… Expand
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2004
2004
Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713.
This study investigated the effects and selectivity of ONO-AE-248, ONO-DI-004, ONO-8711 and ONO-8713 on EP1 and EP3 receptors in… Expand
2002
2002
Gastric ulcerogenic responses following barrier disruption in knockout mice lacking prostaglandin EP1 receptors
Endogenous prostaglandins (PGs) are considered to play a pivotal role in maintaining the mucosal integrity of the stomach after… Expand
Highly Cited
2001
Highly Cited
2001
Biological activities of glucagon-like peptide-1 analogues in vitro and in vivo.
Studies support a role for glucagon-like peptide 1 (GLP-1) as a potential treatment for diabetes. However, since GLP-1 is rapidly… Expand
Highly Cited
2001
Highly Cited
2001
Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development.
Levels of prostaglandin E(2) (PGE(2)) in human and rodent breast cancers are higher than surrounding normal tissues. PGE(2… Expand
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Highly Cited
2001
Highly Cited
2001
A Prostaglandin E2 Receptor Subtype EP1 Receptor Antagonist (ONO-8711) Reduces Hyperalgesia, Allodynia, and C-fos Gene Expression in Rats with Chronic Nerve Constriction
Chronic constriction injury (CCI) of the sciatic nerve in rats induces persistent mechanical hyperalgesia and allodynia. CCI is… Expand
Highly Cited
2001
Highly Cited
2001
The Effects of Peripheral Administration of a Novel Selective Antagonist for Prostaglandin E Receptor Subtype EP1, ONO-8711, in a Rat Model of Postoperative Pain
Mechanically evoked pain, also known as incident pain, induced by coughing or deep breathing after surgery leads to potentially… Expand
Highly Cited
2000
Highly Cited
2000
Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice.
We previously reported that prostaglandin E(2) contributes to colon carcinogenesis through its binding to the prostaglandin E… Expand
Highly Cited
1999
Highly Cited
1999
Role of the prostaglandin E receptor subtype EP1 in colon carcinogenesis.
Although the cyclooxygenase pathway of the arachidonic acid cascade has been suggested to play an important role in colon… Expand
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