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O-(6)-methylguanine

Known as: O(6)-methylguanine, O6-methylguanine, 6-methylguanine 
National Institutes of Health

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2 relations

Broader (1)

Guanine
analogs & derivatives

Papers overview

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Review
2009
Review
2009
Glioblastoma multiforme: a review of where we have been and where we are going
Malignant gliomas such as glioblastoma multiforme (GBM) present some of the greatest challenges in the management of cancer… 
Highly Cited
2008
Highly Cited
2008
Cancer Stem Cell Analysis and Clinical Outcome in Patients with Glioblastoma Multiforme
Purpose: Cancer stem cells (CSC) are thought to represent the population of tumorigenic cells responsible for tumor development… 
Highly Cited
2007
Highly Cited
2007
Temozolomide as Monotherapy Is Effective in Treatment of Advanced Malignant Neuroendocrine Tumors
Purpose: A retrospective analysis of the toxicity and efficacy of temozolomide in advanced neuroendocrine tumors. Experimental… 
Highly Cited
2005
Highly Cited
2005
Human MutScv recognizes damaged DNA base pairs containing 06-methylguanine, 04-methylthymine, or the cisplatin-d(GpG) adduct
Bacterial and mammalian mismatch repair systems have been implicated in the cellular response to certain types of DNA damage, and… 
Highly Cited
2001
Highly Cited
2001
p53 effects both the duration of G2/M arrest and the fate of temozolomide-treated human glioblastoma cells.
Temozolomide (TMZ) is a DNA-methylating agent that has recently been introduced into Phase II and III trials for the treatment of… 
Highly Cited
1992
Highly Cited
1992
Inhibition of tobacco-specific nitrosamine-induced lung tumorigenesis in A/J mice by green tea and its major polyphenol as antioxidants.
Highly Cited
1990
Highly Cited
1990
Depletion of mammalian O6-alkylguanine-DNA alkyltransferase activity by O6-benzylguanine provides a means to evaluate the role of this protein in protection against carcinogenic and therapeutic…
O6-Alkylguanine-DNA alkyltransferase was rapidly and irreversibly inactivated by exposure to O6-benzylguanine or the p… 
Highly Cited
1984
Highly Cited
1984
In vivo mutagenesis by O6-methylguanine built into a unique site in a viral genome.
The mutagenicity of O6-methylguanine (O6MeGua), a chemical carcinogen-DNA adduct, has been studied in vivo by using a single… 
Highly Cited
1980
Highly Cited
1980
Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains
We have identified a group of 8 (among 39) human tumour cell strains deficient in the ability to support the growth of adenovirus… 
Highly Cited
1970
Highly Cited
1970
Methylation of deoxyribonucleic acid in cultured mammalian cells by N-methyl-N'-nitro-N-nitrosoguanidine. The influence of cellular thiol concentrations on the extent of methylation and the 6-oxygen…
1. In neutral aqueous solution N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) yields salts of nitrocyanamide as u.v.-absorbing… 
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