Defective repair of alkylated DNA by human tumour and SV40-transformed human cell strains


We have identified a group of 8 (among 39) human tumour cell strains deficient in the ability to support the growth of adenovirus 5 preparations treated with N-methyl-N′-nitro-N-nitrosoguanidine (MNNG), but able to support the growth of non-treated adenovirus normally1,2. This deficient behaviour defines the Mer− phenotype2. Strains having the Mer… (More)
DOI: 10.1038/288724a0


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