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Nucleosidases

Known as: Hydrolases, Nucleoside, Nucleoside Hydrolases 
N-GLYCOSYL HYDROLASES that catalyze the hydrolysis of the N-glycosidic bond of nucleoside-linked sugars.
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

Glycoside HydrolasesN-Glycosyl Hydrolases
Nucleosides

Narrower (1)

Purine nucleosidase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2011
Highly Cited
2011
Arabidopsis nucleoside hydrolases involved in intracellular and extracellular degradation of purines.
Recently, the first plant nucleoside hydrolase, NSH1 (former designation URH1), was identified at the molecular level. This… 
2010
2010
Adaptive Immunity against Leishmania Nucleoside Hydrolase Maps Its C-Terminal Domain as the Target of the CD4+ T Cell–Driven Protective Response
Nucleoside hydrolases (NHs) show homology among parasite protozoa, fungi and bacteria. They are vital protagonists in the… 
Highly Cited
2007
Highly Cited
2007
Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases.
Transition states can be predicted from an enzyme's affinity to related transition-state analogues. 5'-Methylthioadenosine… 
Review
2003
Review
2003
Catalysis by nucleoside hydrolases.
2003
2003
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.
The 8-aza-immucillins (8-aza-9-deazapurines linked from C9 to C1 of 1,4-dideoxy-1,4-iminoribitol) have been designed as… 
Highly Cited
1999
Highly Cited
1999
Nucleoside Hydrolase from Leishmania major
Protozoan parasites lack the pathway of thede novo synthesis of purines and depend on host-derived nucleosides and nucleotides to… 
Highly Cited
1999
Highly Cited
1999
Iminoribitol transition state analogue inhibitors of protozoan nucleoside hydrolases.
Nucleoside N-ribohydrolases from protozoan parasites are targets for inhibitor design in these purine-auxotrophic organisms… 
Highly Cited
1996
Highly Cited
1996
Three-dimensional structure of the inosine-uridine nucleoside N-ribohydrolase from Crithidia fasciculata.
Protozoan parasites rely on the host for purines since they lack a de novo synthetic pathway. Crithidia fasciculata salvages… 
Review
1985
Review
1985
Leishmania mexicana: purine-metabolizing enzymes of amastigotes and promastigotes.
1984
1984
Nucleoside hydrolases from Trypanosoma cruzi.
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