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The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.
TLDR
The presence of electroneutral, amiloride-resistant, thiazide-sensitive, transepithelial NaCl absorption in mouse CCDs is demonstrated and a role for this transporter in the regulation of fluid homeostasis in mice is suggested. Expand
Imiquimod applied topically: a novel immune response modifier and new class of drug.
TLDR
Imiquimod is expected to be effective where exogenous IFN-alpha has shown utility and where enhancement of cell-mediated immunity is needed and will likely lead to benefits in several other chronic virus infections and tumors of the skin. Expand
Modulation of TH1 and TH2 cytokine production with the immune response modifiers, R-848 and imiquimod.
TLDR
The data suggest that imiquimod and R-848 may have clinical utility in diseases where cell-mediated immune responses are important and in diseases associated with overexpression of IL-4 or IL-5 such as atopic disease. Expand
Anaphylaxis in the United States: an investigation into its epidemiology.
TLDR
The occurrence of anaphylaxis in the US is not as rare as is generally believed and may, in fact, affect 1.21% to 15.4% of the US population. Expand
Thymidine kinase from herpes simplex virus phosphorylates the new antiviral compound, 9-(2-hydroxyethoxymethyl)guanine.
TLDR
Low acyclo-Guo phosphorylating levels in cells infected with either of two herpes simplex virus mutants or with vaccinia virus correlated with low effectiveness of the compound against the virus in tissue culture. Expand
Purification and macromolecular properties of a sialic acid-specific lectin from the slug Limax flavus.
TLDR
Bovine submaxillary mucin, a sialoprotein, was a potent inhibitor of hemagglutination by LFA and loss of inhibitory activity was observed which was proportional to the loss of sialic acid from the mucin. Expand
Effect of Ultraviolet Light on Mengovirus: Formation of Uracil Dimers, Instability and Degradation of Capsid, and Covalent Linkage of Protein to Viral RNA
TLDR
The two observations seem to be causally related, since irradiation of isolated viral RNA did not result in an increase in sedimentation rate of the RNA, even though uracil dimer formation in viral RNA occurred at about the same rate and to the same extent whether intact virions or viral RNA were irradiated. Expand
Cytokine induction in hairless mouse and rat skin after topical application of the immune response modifiers imiquimod and S-28463.
TLDR
It is demonstrated that imiquimod and S-28463 stimulate production of cytokines in the skin after topical application, which may play a major role in its activity in genital wart patients. Expand
Cellular requirements for cytokine production in response to the immunomodulators imiquimod and S-27609.
TLDR
The cell population responsible for the majority of cytokine release in human PBMC in response to S-27609 and imiquimod is a E rosette-, CD14+, CD36+, HLA-DR+ monocyte. Expand
Systems-level analysis of cell-specific AQP2 gene expression in renal collecting duct
TLDR
The results implicate ETS family TRs in cell-specific expression of AQP2 and point to HOX, RXR, CREB and GATAFamily TRs as playing likely additional roles. Expand
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