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Purine metabolism in Toxoplasma gondii.
We have studied the incorporation and interconversion of purines into nucleotides by freshly isolated Toxoplasma gondii. They did not synthesize nucleotides from formate, glycine, or serine. TheExpand
Biochemistry and Molecular Biology of Parasites
E. Ullu and T. Nilsen, Molecular Biology of Protozoan and Helminth Parasites. F.R. Opperdoes, Carbohydrate and Energy Metabolism in Aerobic Protozoa. G.H. Coombs and M. Muller, Energy Metabolism inExpand
Decreasing reliability of acid-fast smear techniques for detection of tuberculosis.
The ability of any screening test to correctly identify diseased patients is directly related to the prevalence of the disease in question. The continuing use of smears for the detection of acid-fastExpand
Guidelines for improving the use of antimicrobial agents in hospitals: a statement by the Infectious Diseases Society of America.
This is the first in a series of reports being prepared by the Infectious Diseases Society of America (IDSA) that will deal with issues in antimicrobial therapy. Antimicrobial agents are often usedExpand
Inhibition of growth of Toxoplasma gondii by qinghaosu and derivatives.
The antimalarial compound qinghaosu (artemisinin) was tested in vitro for the ability to inhibit plaque formation by Toxoplasma gondii in fibroblasts. Qinghaosu at 0.4 microgram/ml for 5 daysExpand
Purine metabolism in Leishmania donovani and Leishmania braziliensis.
We have studied purine metabolism in the culture forms of Leishmania donovani and Leishmania braziliensis. These organisms are incapable of synthesizing purines de novo from glycine, serine, orExpand
Antitrypanosomal effect of allopurinol: conversion in vivo to aminopyrazolopyrimidine nucleotides by Trypanosoma curzi.
The parasite Trypanosoma cruzi metabolizes allopurinol by a sequential conversion to allopurinol mononucleotide and aminopurinol mononucleotide. The latter is incorporated into RNA. ThisExpand
Chemotherapy for Chagas' disease: a perspective of current therapy and considerations for future research.
Our current knowledge of the biology of Trypanosoma cruzi and its relation to the development of chemotherapy for Chagas' disease are reviewed. This includes recent developments in the understandingExpand
Variation in the Susceptibility of Strains of Staphylococcus aureus to Oxacillin, Cephalothin, and Gentamicin
Three cases of staphylococcal bacteremia caused by organisms that were inhibited by low concentrations of oxacillin, but were resistant to the killing effects of oxacillin, stimulated us to screen 60Expand
Purine and pyrimidine salvage pathways in Leishmania donovani.
Leishmania donovani, grown in culture, salvaged radiolabeled purine bases which were distributed into adenine and guanine ribonucleotides and into the RNA of these cells. De novo synthesis of purinesExpand