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Nuclear Receptor Subfamily 4, Group A, Member 1

Known as: NR4A1, Orphan Nuclear Receptor NGFI-B, Orphan Nuclear Receptor TR3 
An orphan nuclear receptor that is closely related to members of the thyroid-steroid receptor gene family. It was originally identified in NERVE… 
National Institutes of Health

Related topics

Related topics

36 relations
Apoptosis PromoterBiologic DevelopmentCell Differentiation processCell Nucleus

Narrower (1)

NR4A1 protein, human

Broader (1)

Receptors, Steroid

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Effects of melatonin on fatty liver disease: The role of NR4A1/DNA‐PKcs/p53 pathway, mitochondrial fission, and mitophagy
Mitochondrial dysfunction has been implicated in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) through poorly… 
Highly Cited
2015
Highly Cited
2015
Patrolling monocytes control tumor metastasis to the lung
Monocytes block tumor access to the lung Metastatic cancer is especially hard to treat. In order to find potential new… 
Review
2010
Review
2010
Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.
Numerous members of the nuclear hormone receptor (NR) superfamily have been demonstrated to regulate metabolic function in a cell… 
Highly Cited
2002
Highly Cited
2002
Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways.
Nur factors are critical for proopiomelanocortin (POMC) induction by CRH in corticotrophs, but the pathways linking CRH to Nur… 
Review
2001
Review
2001
DNA viruses and viral proteins that interact with PML nuclear bodies
Connections between PML nuclear bodies (PML NBs) and DNA virus replication have been investigated from the earliest days of the… 
Highly Cited
1999
Highly Cited
1999
Heterodimerization between Members of the Nur Subfamily of Orphan Nuclear Receptors as a Novel Mechanism for Gene Activation
ABSTRACT We have recently shown that the orphan nuclear receptor Nur77 (NGFI-B) is most active in transcription when it is… 
Highly Cited
1997
Highly Cited
1997
Novel dimeric Nur77 signaling mechanism in endocrine and lymphoid cells
Within the nuclear receptor family, Nur77 (also known as NGFI-B) distinguishes itself by its ability to bind a target sequence… 
Highly Cited
1995
Highly Cited
1995
Unimpaired thymic and peripheral T cell death in mice lacking the nuclear receptor NGFI-B (Nur77).
T cell hybridomas require the immediate-early gene NGFI-B (nur77) for T cell receptor (TCR)-mediated apoptosis, a model for… 
Highly Cited
1991
Highly Cited
1991
Nucleocytoplasmic shuttling of the progesterone receptor.
The nuclear localization of the progesterone receptor is mediated by two signal sequences: one is constitutive and lies in the… 
Highly Cited
1990
Highly Cited
1990
Differential expression of immediate early genes in the hippocampus and spinal cord
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