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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
TLDR
It is demonstrated that increased Nmnat activity is responsible for the axon-sparing activity of the Wlds protein and that SIRT1, a mammalian ortholog of Sir2, is the downstream effector of increased NMNat activity that leads to axonal protection. Expand
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.
TLDR
It is shown that eNampt does not exert insulin-mimetic effects in vitro or in vivo but rather exhibits robust NAD biosynthetic activity, suggesting a vital framework for the regulation of glucose homeostasis. Expand
Resveratrol stimulates AMP kinase activity in neurons
TLDR
It is shown that resveratrol activated AMPK in Neuro2a cells and primary neurons in vitro as well as in the brain, suggesting that neuronal activation of AMPK by resver atrol could affect neuronal energy homeostasis and contribute to the neuroprotective effects of resverAtrol. Expand
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
TLDR
Comparison of sciatic nerve gene expression profiles during development and after crush injury with those of Egr2Lo/Lo Schwann cells revealed that they are developmentally arrested, with down- regulation of myelination-related genes and up-regulation of genes associated with immature and promyelinating Schwann Cells. Expand
Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex
TLDR
Artemin is a survival factor for sensory and sympathetic neurons in culture and its expression pattern suggests that it also influences these neurons in vivo, indicating that like GDNF and NTN, Artemin has a preferred receptor (GFRalpha3-RET) but that alternative receptor interactions also occur. Expand
NS21: Re-defined and modified supplement B27 for neuronal cultures
TLDR
This work re-optimized and modified earlier published formulations of B27 using 21 different ingredients (NS21) and found that holo-transferrin used in NS21 is preferable over apo- transferrinused in B27 for the quality of neuronal cultures. Expand
A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.
TLDR
One of the complementary DNA clones that was rapidly induced by NGF was found to have a nucleotide sequence that predicts a 54-kilodalton protein with homology to transcriptional regulatory proteins. Expand
Molecular Identification of Rapidly Adapting Mechanoreceptors and Their Developmental Dependence on Ret Signaling
TLDR
It is found that the "early Ret(+)" DRG neurons are RA mechanoreceptors, which form Meissner corpuscles, Pacinian corpuscules, and longitudinal lanceolate endings, and Ret signaling is required for the assembly of neural circuits underlying touch perception. Expand
Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse
TLDR
In the mature animal, receptor expression was more limited than in the embryo, and the possibility that the GDNF factors function in inductive processes during embryonic development and with the recently discovered role of NRTN as a necessary trophic factor for the development of some parasympathetic neurons is consistent. Expand
GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival
TLDR
GPI-anchored GFRalpha1 recruits RET to lipid rafts after GDNF stimulation and results in RET/Src association, indicating proper membrane localization of RET via interaction with a raft-localized, GPI-linked coreceptor is of fundamental importance in GFL signaling. Expand
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