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Increased Nuclear NAD Biosynthesis and SIRT1 Activation Prevent Axonal Degeneration
It is demonstrated that increased Nmnat activity is responsible for the axon-sparing activity of the Wlds protein and that SIRT1, a mammalian ortholog of Sir2, is the downstream effector of increased NMNat activity that leads to axonal protection.
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme.
Resveratrol stimulates AMP kinase activity in neurons
It is shown that resveratrol activated AMPK in Neuro2a cells and primary neurons in vitro as well as in the brain, suggesting that neuronal activation of AMPK by resver atrol could affect neuronal energy homeostasis and contribute to the neuroprotective effects of resverAtrol.
A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor.
- J. Milbrandt
- 6 November 1987
One of the complementary DNA clones that was rapidly induced by NGF was found to have a nucleotide sequence that predicts a 54-kilodalton protein with homology to transcriptional regulatory proteins.
Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
- N. Le, R. Nagarajan, James Y T Wang, T. Araki, R. Schmidt, J. Milbrandt
- BiologyProceedings of the National Academy of Sciences…
- 15 February 2005
Comparison of sciatic nerve gene expression profiles during development and after crush injury with those of Egr2Lo/Lo Schwann cells revealed that they are developmentally arrested, with down- regulation of myelination-related genes and up-regulation of genes associated with immature and promyelinating Schwann Cells.
Artemin, a Novel Member of the GDNF Ligand Family, Supports Peripheral and Central Neurons and Signals through the GFRα3–RET Receptor Complex
NS21: Re-defined and modified supplement B27 for neuronal cultures
Molecular Identification of Rapidly Adapting Mechanoreceptors and Their Developmental Dependence on Ret Signaling
Expression of Neurturin, GDNF, and GDNF Family-Receptor mRNA in the Developing and Mature Mouse
- J. Golden, J. Demaro, P. Osborne, J. Milbrandt, Eugene M. Johnson
- BiologyExperimental Neurology
- 1 August 1999
In the mature animal, receptor expression was more limited than in the embryo, and the possibility that the GDNF factors function in inductive processes during embryonic development and with the recently discovered role of NRTN as a necessary trophic factor for the development of some parasympathetic neurons is consistent.
Mitofusin 2 Is Necessary for Transport of Axonal Mitochondria and Interacts with the Miro/Milton Complex
- A. Misko, Sirui Jiang, I. Wegorzewska, J. Milbrandt, R. Baloh
- BiologyThe Journal of Neuroscience
- 24 March 2010
Evidence is presented that Mfn2 is directly involved in and required for axonal mitochondrial transport, distinct from its role in mitochondrial fusion, and important insight is offered into the cell type specificity and molecular mechanisms of axonal degeneration in CMT2A and dominant optic atrophy.