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Sox18 induces development of the lymphatic vasculature in mice
The lymphatic system plays a key role in tissue fluid regulation and tumour metastasis, and lymphatic defects underlie many pathological states including lymphoedema, lymphangiectasia, lymphangiomaExpand
SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse.
Two lines of evidence suggest that the Sry-related gene Sox9 is important for chondrogenesis in mammalian embryos. Sox9 mRNA is expressed in chondrogenic condensations in mice, and mutations in humanExpand
The NR4A subgroup: immediate early response genes with pleiotropic physiological roles
The nuclear hormone receptor (NR) superfamily includes the orphan NR4A subgroup, comprised of Nur77 (NR4A1), Nurr1 (NR4A2) and NOR-1 (NR4A3). These NRs are classified as early response genes, areExpand
Role of HuR in Skeletal Myogenesis through Coordinate Regulation of Muscle Differentiation Genes
ABSTRACT In this report, we investigate the role of the RNA-binding protein HuR during skeletal myogenesis. At the onset of myogenesis in differentiating C2C12 myocytes and in vivo in regeneratingExpand
A human beta-actin expression vector system directs high-level accumulation of antisense transcripts.
We have constructed a mammalian expression vector consisting of 3 kilobases of the human beta-actin gene 5' flanking sequence plus 5' untranslated region and intervening sequence 1 linked at the 3'Expand
The Peroxisome Proliferator-Activated Receptor β/δ Agonist, GW501516, Regulates the Expression of Genes Involved in Lipid Catabolism and Energy Uncoupling in Skeletal Muscle Cells
Lipid homeostasis is controlled by the peroxisome proliferator-activated receptors (PPARα, -β/δ, and -γ) that function as fatty acid-dependent DNA-binding proteins that regulate lipid metabolism. InExpand
Class I histone deacetylases sequentially interact with MyoD and pRb during skeletal myogenesis.
We describe a functional and biochemical link between the myogenic activator MyoD, the deacetylase HDAC1, and the tumor suppressor pRb. Interaction of MyoD with HDAC1 in undifferentiated myoblastsExpand
Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease.
Numerous members of the nuclear hormone receptor (NR) superfamily have been demonstrated to regulate metabolic function in a cell- and tissue-specific manner. This review brings together recentExpand
Mutations in Sox18 underlie cardiovascular and hair follicle defects in ragged mice
Analysis of classical mouse mutations has been useful in the identification and study of many genes. We previously mapped Sox18, encoding an SRY-related transcription factor, to distal mouseExpand
The orphan nuclear receptor, RORalpha, regulates gene expression that controls lipid metabolism: staggerer (SG/SG) mice are resistant to diet-induced obesity.
Homozygous staggerer mice (sg/sg) display decreased and dysfunctional retinoic acid receptor-related orphan receptor alpha (RORalpha) expression. We observed decreases in serum (and liver)Expand
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