Neutrophil Collagenase

Known as: MMP 8 Metalloproteinase, MMP8 Metalloproteinase, Matrix Metalloproteinase-8 
A member of the MATRIX METALLOPROTEINASES that cleaves triple-helical COLLAGEN types I, II, and III.
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
Matrix metalloproteinases (MMPs) have been implicated in numerous tissue-remodeling processes. The finding that mice deficient in… (More)
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Highly Cited
2004
Highly Cited
2004
As cancer cells traverse collagen-rich extracellular matrix (ECM) barriers and intravasate, they adopt a fibroblast-like… (More)
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Highly Cited
2004
Highly Cited
2004
Little is known about the cell biology or the biologic roles of polymorphonuclear cell (PMN)-derived matrix metalloproteinase-8… (More)
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Highly Cited
2003
Highly Cited
2003
Matrix metalloproteinases (MMPs) have fundamental roles in tumor progression, but most clinical trials with MMP inhibitors have… (More)
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Highly Cited
2002
Highly Cited
2002
AIM To determine the cellular and molecular forms of MMP-8 (collagenase-2) and MMP-13 (collagenase-3) associated with chronic… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND Loss of interstitial collagen, particularly type I collagen, the major load-bearing molecule of atherosclerotic… (More)
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Highly Cited
2000
Highly Cited
2000
OBJECTIVES The mechanisms by which microbial invasion of the amniotic cavity leads to membrane weakening and rupture are poorly… (More)
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Highly Cited
1997
Highly Cited
1997
We demonstrate the direct involvement of increased collagenase activity in the cleavage of type II collagen in osteoarthritic… (More)
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Highly Cited
1996
Highly Cited
1996
This study confirms that normal human articular chondrocytes express neutrophil collagenase or matrix metalloproteinase-8 (MMP-8… (More)
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Highly Cited
1990
Highly Cited
1990
We have identified and sequenced a cDNA encoding human neutrophil collagenase from a lambda gt11 cDNA library constructed from… (More)
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