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Neuregulins

Known as: GGF, NRG protein, ARIA 
Neuregulin (heregulin) polypeptides have been shown to interact with and activate the ErbB2, ErbB3 and ErbB4 receptor proteins, and have been found… 
National Institutes of Health

Related topics

Related topics

27 relations
Cell Differentiation processCell Proliferation Regulatory ProcessExtracellular SpaceGrowth Factor Gene

Narrower (6)

HeregulinNRG1 protein, humanNRG3 protein, humanNeuronal Differentiation Factor, Cholinergic

Broader (2)

Nerve Growth Factorneu Differentiation Factor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2001
Review
2001
Cardiotoxicity in signal transduction therapeutics: erbB2 antibodies and the heart.
Highly Cited
1998
Highly Cited
1998
Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail.
Neuregulins are a multi-isoform family of growth factors that activate members of the erbB family of receptor tyrosine kinases… 
Review
1997
Review
1997
Genetic analysis of postsynaptic differentiation at the vertebrate neuromuscular junction
Highly Cited
1997
Highly Cited
1997
Nerve Terminal Withdrawal from Rat Neuromuscular Junctions Induced by Neuregulin and Schwann Cells
Schwann cells (SCs) that cap neuromuscular junctions (nmjs) play roles in guiding nerve terminal growth in paralyzed and… 
Highly Cited
1996
Highly Cited
1996
Substrate-bound agrin induces expression of acetylcholine receptor epsilon-subunit gene in cultured mammalian muscle cells.
Expression of the epsilon-subunit gene of the acetylcholine receptor (AChR) by myonuclei located at the neuromuscular junction is… 
Highly Cited
1996
Highly Cited
1996
Neu Differentiation Factor/Neuregulin Isoforms Activate Distinct Receptor Combinations*
The multiple isoforms of Neu differentiation factor (NDF/neuregulin) induce a pleiotropic cellular response that is isoform… 
Highly Cited
1996
Highly Cited
1996
Effects of GGF/neuregulins on neuronal survival and neurite outgrowth correlate with erbB2/neu expression in developing rat retina.
We have examined the expression of neuregulin and its putative receptors, erbB2/neu, erbB3 and erbB4/tyro2 during retinal… 
Highly Cited
1996
Highly Cited
1996
Phosphatidylinositol 3-kinase recruitment by p185erbB-2 and erbB-3 is potently induced by neu differentiation factor/heregulin during mitogenesis and is constitutively elevated in growth factor…
Amplification and overexpression of the c-erbB-2 gene in 21MT-2 and 21MT-1 human breast carcinoma cells results in progressively… 
Highly Cited
1990
Highly Cited
1990
Comparative utilization of warm- and cool-season forages by cattle, sheep and goats.
The quality of different classes of forage hay (C3, C4 grasses and legumes) was determined in intake and digestibility trials… 
Highly Cited
1989
Highly Cited
1989
Effects of dietary neutral detergent fiber concentration and supplementary long hay on chewing activities and milk production of dairy cows.
Effects of dietary NDF concentration on chewing and productivity were assessed using silage-based diets with and without… 
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