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Development of the vertebrate neuromuscular junction.
The extent to which the NMJ is a suitable model for development of neuron-neuron synapses is considered, and an additional set of cues biases synapse formation in favor of appropriate partners.
Long-term in vivo imaging of experience-dependent synaptic plasticity in adult cortex
The measurements suggest that sensory experience drives the formation and elimination of synapses and that these changes might underlie adaptive remodelling of neural circuits.
Defective Neuromuscular Synaptogenesis in Agrin-Deficient Mutant Mice
Distinct roles of nerve and muscle in postsynaptic differentiation of the neuromuscular synapse
- Weichun Lin, R. Burgess, Bertha Dominguez, S. Pfaff, J. Sanes, Kuo-Fen Lee
- 26 April 2001
It is reported that the initial steps in postsynaptic differentiation and formation of an end-plate band require MuSK and rapsyn, but are not dependent on agrin or the presence of motor axons, while the subsequent stages of synaptic growth and maintenance require nerve-derived agrin, and a second nerve- derived signal that disperses ectopic post synaptic apparatus.
Use of a recombinant retrovirus to study post‐implantation cell lineage in mouse embryos.
It is shown that a gene introduced into cells of mouse embryos by a retrovirus can serve as a heritable marker for the study of cell lineage in vivo and that several cell types have a pluripotential ancestor and that cell fate is progressively restricted as development proceeds.
Skeletal and Cardiac Myopathies in Mice Lacking Utrophin and Dystrophin: A Model for Duchenne Muscular Dystrophy
Failure of postsynaptic specialization to develop at neuromuscular junctions of rapsyn-deficient mice
It is reported that rapsyn is essential for the formation of AChR clusters, but that synapse-specific transcription of A ChR subunit genes can proceed in its absence.
Syne-1, A Dystrophin- and Klarsicht-related Protein Associated with Synaptic Nuclei at the Neuromuscular Junction*
- E. Apel, Renate M. Lewis, R. Grady, J. Sanes
- BiologyThe Journal of Biological Chemistry
- 13 October 2000
Syne-1 is the first protein found to be selectively associated with synaptic nuclei, and remains synaptically enriched following denervation or degeneration/regeneration, and is also present at high levels in the central nuclei of dystrophic myotubes.
Synaptic structure and development: The neuromuscular junction
Distribution and Function of Laminins in the Neuromuscular System of Developing, Adult, and Mutant Mice
Mutation of the laminin α2 or β2 genes in mice not only leads to loss of the respective chains in both nerve and muscle, but also to coordinate loss and compensatory upregulation of other chains.