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Narrow Therapeutic Index

Known as: NTI 
A therapeutic index of less than 2-fold difference between the median lethal dose and median effective dose values, or less than 2-fold difference… 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
Gut Microbiota and Tacrolimus Dosing in Kidney Transplantation
Tacrolimus dosing to establish therapeutic levels in recipients of organ transplants is a challenging task because of much… 
Review
2010
Review
2010
Drugs with narrow therapeutic index as indicators in the risk management of hospitalised patients
Drugs with narrow therapeutic index (NTI-drugs) are drugs with small differences between therapeutic and toxic doses. The pattern… 
Highly Cited
2010
Highly Cited
2010
Tablet Splitting of a Narrow Therapeutic Index Drug: A Case with Levothyroxine Sodium
Levothyroxine is a narrow therapeutic index, and to avoid adverse effect associated with under or excessive dosage, the dose… 
Highly Cited
2005
Highly Cited
2005
Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series.
Given the mounting evidence for involvement of delta opioid receptors in the tolerance and physical dependence of mu opioid… 
Review
2003
Review
2003
Tacrolimus: a further update of its use in the management of organ transplantation.
UNLABELLED Extensive clinical use has confirmed that tacrolimus (Prograf) is a key option for immunosuppression after… 
Review
2002
Review
2002
Therapeutic drug monitoring of immunosuppressant drugs in clinical practice.
Review
2001
Review
2001
Is the therapeutic index better with gemcitabine-based chemoradiation than with 5-fluorouracil-based chemoradiation in locally advanced pancreatic cancer?
Highly Cited
1991
Highly Cited
1991
Selective blockage of delta opioid receptors prevents the development of morphine tolerance and dependence in mice.
Recently, we demonstrated that delta opioid binding sites are involved in the development of morphine tolerance and dependence… 
Highly Cited
1991
Highly Cited
1991
Differential antagonism of delta opioid agonists by naltrindole and its benzofuran analog (NTB) in mice: evidence for delta opioid receptor subtypes.
In this study naltrindole (NTI) and its benzofuran derivative (NTB) were studied for their antagonist activity against various… 
Highly Cited
1990
Highly Cited
1990
Design of peptidomimetic delta opioid receptor antagonists using the message-address concept.
Highly selective nonpeptide ligands with potent delta opioid receptor antagonist activity have been developed using the message… 
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