Narrow Therapeutic Index

Known as: NTI 
A therapeutic index of less than 2-fold difference between the median lethal dose and median effective dose values, or less than 2-fold difference… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1978-2018
0102019782018

Papers overview

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2010
2010
Levothyroxine is a narrow therapeutic index, and to avoid adverse effect associated with under or excessive dosage, the dose… (More)
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Highly Cited
2005
Highly Cited
2005
Given the mounting evidence for involvement of delta opioid receptors in the tolerance and physical dependence of mu opioid… (More)
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1999
1999
Summary. Narrow therapeutic index (NTI) drugs are agents for which small changes in systemic concentration can lead to… (More)
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Highly Cited
1999
Highly Cited
1999
The dimeric glycoprotein anti-Müllerian hormone (AMH) is a member of the transforming growth factor-b superfamily of growth and… (More)
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Highly Cited
1997
Highly Cited
1997
Several investigators have demonstrated that the opioid pathway is involved in tissue preservation during hypoxia or ischemia and… (More)
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1997
1997
Changes in hypothalamus-pituitary-thyroid function occur in patients with a variety of illnesses and are referred to as the… (More)
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1995
1995
This study demonstrates that the selective delta receptor antagonists ICI 174864 and naltrindole (NTI) attenuate alcohol intake… (More)
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1993
1993
Patients with severe nonthyroidal illnesses (NTIs) frequently have decreased serum concentrations of triiodothyronine (T3) and… (More)
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Highly Cited
1991
Highly Cited
1991
Recently, we demonstrated that delta opioid binding sites are involved in the development of morphine tolerance and dependence… (More)
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Highly Cited
1991
Highly Cited
1991
In this study naltrindole (NTI) and its benzofuran derivative (NTB) were studied for their antagonist activity against various… (More)
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