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NU6102

Known as: O(6)-cyclohexylmethoxy-2-(4'-sulfamoylanilino)purine 
National Institutes of Health

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Broader (1)

Purines

Papers overview

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2016
2016
Differential Regulation of Progesterone Receptor-Mediated Transcription by CDK2 and DNA-PK.
Progesterone receptor (PR) function is altered by cell signaling, but the mechanisms of kinase-specific regulation are not well… 
2012
2012
O 1 Luminescent non-metal probes for the analysis of protein kinases and their inhibitors
Cyclin-dependent kinases (Cdks) are essential for the control of cell cycle transitions, and changes in activity of a single Cdk1… 
2010
2010
Synthesis of sulfonamide-based kinase inhibitors from sulfonates by exploiting the abrogated SN2 reactivity of 2,2,2-trifluoroethoxysulfonates.
The attenuated S(N)2 reactivity of the 2,2,2-trifluoroethyl group has been exploited for the synthesis of a series of 6… 
2009
2009
The kinase inhibitor O 6-cyclohexylmethylguanine ( NU 2058 ) potentiates the cytotoxicity of cisplatin by mechanisms that are independent of its effect upon CDK 2
O-Cyclohexylmethylguanine (NU2058) was developed as an inhibitor of CDK2 and was previously shown to potentiate cisplatin… 
2008
2008
[abstract] Preclinical in vitro and in vivo evaluation of the cyclin dependent kinase 2 inhibitor NU6102 and a water pro-drug NU6301
2005
2005
Study of a ligand complexed with Cdk2/Cdk4 by computer simulation
AbstractCyclin-dependent kinases (Cdks) play important roles in the regulation of the cell cycle. Their inhibitors have entered… 
2005
2005
Comparative activity of the potent selective CDK2 inhibitor NU6102 in CDK2 wild-type and knock-out mouse embryo fibroblasts
4409 Cyclin-dependent kinases (CDK) regulate cell cycle progression, and CDK deregulation due to cyclin over-expression, mutation… 
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