Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

NU6102

Known as: O(6)-cyclohexylmethoxy-2-(4'-sulfamoylanilino)purine 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Background:The phosphatidylinositol-3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway is commonly deregulated in human… Expand
  • table 1
  • table 2
  • figure 1
  • figure 2
  • figure 3
Is this relevant?
2016
2016
Progesterone receptor (PR) function is altered by cell signaling, but the mechanisms of kinase-specific regulation are not well… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2015
2015
Irreversible inhibitors that modify cysteine or lysine residues within a protein kinase ATP binding site offer, through their… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2011
2011
To facilitate the evaluation of CDK2 (cyclin-dependent kinase 2) as a cancer target, the in vitro and in vivo properties of… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
Is this relevant?
2010
2010
Background:Cellular proliferation, driven by cyclin-dependent kinases (CDKs) and their cyclin partners, is deregulated in cancer… Expand
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
2010
2010
The attenuated S(N)2 reactivity of the 2,2,2-trifluoroethyl group has been exploited for the synthesis of a series of 6… Expand
Is this relevant?
2009
2009
O(6)-Cyclohexylmethylguanine (NU2058) was developed as an inhibitor of CDK2 and was previously shown to potentiate cisplatin… Expand
Is this relevant?
2005
2005
Inhibition of protein kinase activity is a focus of intense drug discovery efforts in several therapeutic areas. Major challenges… Expand
Is this relevant?
2005
2005
AbstractCyclin-dependent kinases (Cdks) play important roles in the regulation of the cell cycle. Their inhibitors have entered… Expand
Is this relevant?
2004
2004
The adenosine 5'-triphosphate (ATP) competitive cyclin-dependent kinase inhibitor O(6)-cyclohexylmethylguanine (NU2058, 1) has… Expand
Is this relevant?