• Publications
  • Influence
Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family.
  • B. Hagenbuch, C. Gui
  • Biology, Chemistry
    Xenobiotica; the fate of foreign compounds in…
  • 2008
TLDR
This review summarizes the general features and the substrates of the eleven human OATPs and reviews what is known about the mechanism of their multispecificity, their predicted structure, their role in drug-food interactions, and their roles in cancer.
Development of a Cell-Based High-Throughput Assay to Screen for Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3
TLDR
A cell-based high-throughput assay to screen chemical libraries in order to identify specific inhibitors for OATP1B1- and OATp1B3-mediated FMTX uptake IC50 values was developed.
Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3.
Amino acid residues in transmembrane domain 10 of organic anion transporting polypeptide 1B3 are critical for cholecystokinin octapeptide transport.
TLDR
Three key residues within TM10, namely, Y537, S545, and T550, are identified that are important for CCK-8 transport and molecular modeling indicated that two of the three identified residues might form hydrogen bonds with CCk-8.
Cinanserin Is an Inhibitor of the 3C-Like Proteinase of Severe Acute Respiratory Syndrome Coronavirus and Strongly Reduces Virus Replication In Vitro
TLDR
It is demonstrated that the old drug cinanserin is an inhibitor of SARS-CoV replication, acting most likely via inhibition of the 3CL proteinase.
Ligand‐binding regulation of LXR/RXR and LXR/PPAR heterodimerizations: SPR technology‐based kinetic analysis correlated with molecular dynamics simulation
TLDR
It is found that LXRs could bind to all the three PPAR subtypes, PPARα,PPARγ and PPARδ with different binding affinities, and such receptor/receptor interactions could be regulated by ligand binding.
Role of transmembrane domain 10 for the function of organic anion transporting polypeptide 1B1
  • C. Gui, B. Hagenbuch
  • Biology, Chemistry
    Protein science : a publication of the Protein…
  • 1 November 2009
TLDR
Results show that transmembrane domain 10 is critical for the function of OATP1B1, and four amino acid residues, namely L545, F546, L550, and S554 in TM10, whose simultaneous mutation caused almost complete loss of OatP 1B1‐mediated estrone‐3‐sulfate transport.
Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A
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