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The genetic cause underlying the development of multiple colonic adenomas, the premalignant precursors of colorectal cancer (CRC… Expand Oxidatively induced DNA lesions have been implicated in the etiology of many diseases (including cancer) and in aging. Repair of… Expand The oxidatively induced DNA lesions 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyG) and 4,6-diamino-5-formamidopyrimidine… Expand Repair of oxidatively damaged bases in the genome via the base excision repair pathway is initiated with excision of these… Expand DNA damage mediated by reactive oxygen species generates miscoding and blocking lesions that may lead to mutations or cell death… Expand The relationship of trehalose metabolism to fungal virulence was explored in the rice blast fungus Magnaporthe grisea. To… Expand 8-oxoguanine (8-oxoG), ring-opened purines (formamidopyrimidines or Fapys), and other oxidized DNA base lesions generated by… Expand Thymine glycol, a potentially lethal DNA lesion produced by reactive oxygen species, can be removed by DNA glycosylase… Expand The present state of knowledge of the role of trehalose and trehalose hydrolysis catalyzed by trehalase (EC 188.8.131.52) in the… Expand Repair of oxidative damage to DNA bases is essential to prevent mutations and cell death. Endonuclease III is the major DNA… Expand