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Antimalarial drug discovery: efficacy models for compound screening
- D. Fidock, P. Rosenthal, S. Croft, R. Brun, S. Nwaka
- Biology, MedicineNature reviews. Drug discovery
- 1 June 2004
Different in vitro and in vivo screens for antimalarial drug discovery are suggested and a streamlined process for evaluating new compounds on the path from drug discovery to development is recommended.
Innovative lead discovery strategies for tropical diseases
The different approaches to lead discovery for tropical diseases are discussed and a coordination strategy that involves highly integrated partnerships and networks between scientists in academic institutions and industry in both wealthy industrialized countries and disease-endemic countries is emphasized.
Expression and Function of the Trehalase Genes NTH1 and YBR0106 in Saccharomyces cerevisiae(*)
It is shown here that only the most upstream start codon which initiates translation of the longest possible ORF is used for expression of NTH1 in vivo, and a requirement of the intact YBR0106 gene for thermotolerance is demonstrated in experiments with the respective mutants.
Induction of neutral trehalase Nth1 by heat and osmotic stress is controlled by STRE elements and Msn2/Msn4 transcription factors: variations of PKA effect during stress and growth
There is direct evidence that Msn2/Msn4 and the STREs control the heat‐, osmotic stress‐ and diauxic shift‐dependent induction of Nth1, and expression of enzymes oftrehalose synthesis and hydrolysis help to maintain trehalose concentration during stress.
Phenotypic features of trehalase mutants in Saccharomyces cerevisiae
Deletion of the ATH1 gene in Saccharomyces cerevisiae prevents growth on trehalose
Genomic-scale prioritization of drug targets: the TDR Targets database
The development of the TDR Targets database is discussed, which encompasses extensive genetic, biochemical and pharmacological data related to tropical disease pathogens, as well as computationally predicted druggability for potential targets and compound desirability information, and aims to facilitate the identification and prioritization of candidate drug targets for pathogens.
Neutral trehalase Nth1p of Saccharomyces cerevisiae encoded by the NTH1 gene is a multiple stress responsive protein
Molecular biology of trehalose and the trehalases in the yeast Saccharomyces cerevisiae.
Schistosomes: challenges in compound screening
- Bernadette Ramirez, Q. Bickle, Fouad Yousif, Foluke Fakorede, M. Mouries, S. Nwaka
- Biology, MedicineExpert Opinion on Drug Discovery
- 1 October 2007
The present state of in vitro and in vivo drug screening strategies against schistosomes is reviewed and the best practices for compound screening in the TDR-designated compound screening centres are highlighted and some of the challenges involved are details.