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NPC1L1 gene

Known as: NPC1L1, NPC1 like 1, NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 Gene 
This gene plays a role in lipid transport.
National Institutes of Health

Related topics

Related topics

6 relations
Cholesterol HomeostasisHomo sapiensLigand BindingLipid Transport

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Structure-activity relationship study of non-steroidal NPC1L1 ligands identified through cell-based assay using pharmacological chaperone effect as a readout.
2013
2013
Ezetimibe Inhibits Hepatic Niemann-Pick C1-Like 1 to Facilitate Macrophage Reverse Cholesterol Transport in Mice
Objective—Controversies have arisen from recent mouse studies about the essential role of biliary sterol secretion in reverse… 
2013
2013
Structure-activity relationship studies of Niemann-Pick type C1-like 1 (NPC1L1) ligands identified by screening assay monitoring pharmacological chaperone effect.
2011
2011
Dietary cholesterol induces trafficking of intestinal Niemann-Pick Type C1 Like 1 from the brush border to endosomes.
The transmembrane protein Niemann-Pick C1 Like 1 (NPC1L1) belongs to the Niemann-Pick C1 (NPC1) family of cholesterol… 
2010
2010
A SNP of NPC1L1 affects cholesterol absorption in Japanese.
AIM Ezetimibe is known to target Niemann-Pick Type C1 Like1 (NPC1L1), a key protein in intestinal cholesterol absorption, and… 
Review
2010
Review
2010
Transporters as Drug Targets: Discovery and Development of NPC1L1 Inhibitors
The potent cholesterol absorption inhibitor ezetimibe was developed as a first‐in‐class drug for treating hypercholesterolemia… 
2009
2009
Spiroimidazolidinone NPC1L1 inhibitors. 1: Discovery by 3D-similarity-based virtual screening.
2008
2008
Madin-Darby Canine Kidney II Cells: A Pharmacologically Validated System for NPC1L1-Mediated Cholesterol Uptake
Absorption of dietary cholesterol in the proximal region of the intestine is mediated by Niemann-Pick C1-like protein (NPC1L1… 
Review
2008
Review
2008
Cholesterol and non-cholesterol sterol transporters: ABCG5, ABCG8 and NPC1L1: a review.
  • S. KidambiS. Patel
  • Xenobiotica; the fate of foreign compounds in…
  • 2008
  • Corpus ID: 29825809
1. Whole-body sterol (cholesterol and xenosterol) balance is delicately regulated by the gastrointestinal tract and liver, which… 
Highly Cited
2007
Highly Cited
2007
Genes that affect cholesterol synthesis, cholesterol absorption, and chylomicron assembly: the relationship between the liver and intestine in control and streptozotosin diabetic rats.
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