NPC1L1 gene

Known as: NPC1L1, NPC1 like 1, NPC1 (Niemann-Pick Disease, Type C1, Gene)-Like 1 Gene 
This gene plays a role in lipid transport.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
0204020002017

Papers overview

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Highly Cited
2008
Highly Cited
2008
Niemann-Pick C1-like 1 (NPC1L1) is a polytopic transmembrane protein that plays a critical role in cholesterol absorption… (More)
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Highly Cited
2006
Highly Cited
2006
An approach to understand quantitative traits was recently proposed based on the finding that nonsynonymous (NS) sequence… (More)
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Highly Cited
2006
Highly Cited
2006
Although NPC1L1 is required for intestinal cholesterol absorption, data demonstrating mechanisms by which this protein… (More)
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Highly Cited
2005
Highly Cited
2005
Ezetimibe is a potent inhibitor of cholesterol absorption that has been approved for the treatment of hypercholesterolemia, but… (More)
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Highly Cited
2005
Highly Cited
2005
Peroxisome proliferator-activated receptors (PPARs) control the transcription of genes involved in lipid metabolism. Activation… (More)
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Highly Cited
2005
Highly Cited
2005
NPC1L1, a recently identified relative of Niemann-Pick C1, was characterized to determine its subcellular location and potential… (More)
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Highly Cited
2005
Highly Cited
2005
Data suggest that intestinal carotenoid absorption is a facilitated process. The present study was conducted to determine whether… (More)
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Highly Cited
2004
Highly Cited
2004
Niemann-Pick C1 Like 1 (NPC1L1) is a protein localized in jejunal enterocytes that is critical for intestinal cholesterol… (More)
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Highly Cited
2004
Highly Cited
2004
Dietary cholesterol consumption and intestinal cholesterol absorption contribute to plasma cholesterol levels, a risk factor for… (More)
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Highly Cited
2000
Highly Cited
2000
Niemann-Pick type C1 (NPC1) disease is caused by defects in the NPC1 protein, which result in perturbation of subcellular… (More)
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