NOX4 gene

Known as: NADPH OXIDASE 4, KOX, NOX4 
This gene plays a role as an oxygen sensor in signal transduction.
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
RATIONALE The function of Nox4, a source of vascular H(2)O(2), is unknown. Other Nox proteins were identified as mediators of… (More)
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Highly Cited
2010
Highly Cited
2010
NADPH oxidases are important sources of reactive oxygen species (ROS), possibly contributing to various disorders associated with… (More)
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Highly Cited
2010
Highly Cited
2010
RATIONALE NADPH oxidases are a major source of superoxide (O(2)(-)) in the cardiovascular system. The function of Nox4, a member… (More)
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Highly Cited
2009
Highly Cited
2009
Oxidative stress is implicated in human diseases. Some of the oxidative pathways are harbored in the mitochondria. NAD(P)H… (More)
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Highly Cited
2009
Highly Cited
2009
RATIONALE NADPH oxidases (Noxes) regulate vascular physiology and contribute to the pathogenesis of vascular disease. In vascular… (More)
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Highly Cited
2007
Highly Cited
2007
NOX4 is an enigmatic member of the NOX (NADPH oxidase) family of ROS (reactive oxygen species)-generating NADPH oxidases. NOX4… (More)
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Highly Cited
2007
Highly Cited
2007
OBJECTIVE The mechanisms responsible for maintaining the differentiated phenotype of adult vascular smooth muscle cells (VSMCs… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVE Reactive oxygen species (ROS) that act as signaling molecules in vascular smooth muscle cells (VSMC) and contribute to… (More)
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Highly Cited
2004
Highly Cited
2004
Insulin stimulation of target cells elicits a burst of H(2)O(2) that enhances tyrosine phosphorylation of the insulin receptor… (More)
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Highly Cited
2001
Highly Cited
2001
gp91phox is the catalytic subunit of the respiratory burst oxidase, an NADPH-dependent, superoxide generating enzyme present in… (More)
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