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NOV 002
Known as:
NOV-002
, NOV002
, Oxidized Glutathione NOV-002
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A stabilized formulation of disodium glutathione disulfide (GSSG; oxidized glutathione) and cisplatin (1000:1) with potential chemoprotective and…
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National Institutes of Health
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Related topics
Related topics
3 relations
Broader (3)
Cisplatin
Drug Combinations
Glutathione Disulfide
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
NOV-002, A Glutathione Disulfide Mimetic, Suppresses Tumor Cell Invasion and Metastasis
K. Gumireddy
,
Anping Li
,
+5 authors
Qihong Huang
Journal of Carcinogenesis & Mutagenesis
2013
Corpus ID: 13993617
Metastasis is the major cause of death in cancer. Most therapies currently in the clinic aim to eradicate primary tumor, but do…
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Highly Cited
2012
Highly Cited
2012
Phase 2 study of neoadjuvant treatment with NOV-002 in combination with doxorubicin and cyclophosphamide followed by docetaxel in patients with HER-2 negative clinical stage II–IIIc breast cancer
A. Montero
,
C. Diaz-Montero
,
+14 authors
S. Glück
Breast Cancer Research and Treatment
2012
Corpus ID: 24517605
NOV-002 (a formulation of disodium glutathione disulfide) modulates signaling pathways involved in tumor cell proliferation and…
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2012
2012
The glutathione disulfide mimetic NOV-002 inhibits cyclophosphamide-induced hematopoietic and immune suppression by reducing oxidative stress.
C. Diaz-Montero
,
Yong Wang
,
+5 authors
Daohong Zhou
Free Radical Biology & Medicine
2012
Corpus ID: 29987110
Review
2011
Review
2011
Cellular Redox Pathways as a Therapeutic Target in the Treatment of Cancer
A. Montero
,
J. Jassem
Drugs
2011
Corpus ID: 22678600
The vulnerability of some cancer cells to oxidative signals is a therapeutic target for the rational design of new anticancer…
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2010
2010
A randomized, open-label, phase III trial of NOV-002 in combination with paclitaxel (P) and carboplatin (C) versus paclitaxel and carboplatin alone for the treatment of advanced non-small cell lung…
P. Fidias
,
T. Ciuleanu
,
+5 authors
T. Lynch
Journal of Clinical Oncology
2010
Corpus ID: 654642
LBA7007 Background: NOV-002 is a formulation of disodium glutathione disulfide (GSSG). GSSG is a naturally occurring substance…
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2009
2009
Daily injections of the glutathione disulfide mimetic NOV-002 ameliorates hematologic toxicities from neoadjuvant chemotherapy in breast cancer patients enrolled in the NEO-NOVO trial, and…
C. Diaz-Montero
,
N. Paphitis
,
+7 authors
A. Montero
2009
Corpus ID: 71453134
CTRC-AACR San Antonio Breast Cancer Symposium: 2008 Abstracts Abstract #2141 Background: Chemotherapy induced anemia is a…
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Highly Cited
2008
Highly Cited
2008
NOV-002, a glutathione disulfide mimetic, as a modulator of cellular redox balance.
D. Townsend
,
Lin He
,
S. Hutchens
,
Tracy E. Garrett
,
C. Pazoles
,
K. Tew
Cancer Research
2008
Corpus ID: 652788
NOV-002 is a novel glutathione disulfide mimetic that when administered in combination with standard chemotherapeutic regimens…
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Review
2008
Review
2008
NOV-002, a mimetic of glutathione disulfide
D. Townsend
,
C. Pazoles
,
K. Tew
Expert Opinion on Investigational Drugs
2008
Corpus ID: 21573076
Background: Oxidative signaling to modulate redox-sensitive cell functions is a heretofore unexploited approach to developing new…
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2006
2006
NOV-002, a chemoprotectant/immunomodulator, added to first-line carboplatin/paclitaxel in advanced non-small cell lung cancer (NSCLC): A randomized Phase 1/2, open-label, controlled study.
C. Pazoles
,
H. Gerstein
Journal of Clinical Oncology
2006
Corpus ID: 24078772
17021 Background: NOV-002 is a proprietary formulation of oxidized glutathione that modulates production of cytokines and…
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Review
2005
Review
2005
Glutathione S-transferases as regulators of kinase pathways and anticancer drug targets.
D. Townsend
,
Victoria Findlay
,
K. Tew
Methods in Enzymology
2005
Corpus ID: 8110858
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