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Increased circulating myeloid-derived suppressor cells correlate with clinical cancer stage, metastatic tumor burden, and doxorubicin–cyclophosphamide chemotherapy
Abnormal accumulation of myeloid-derived suppressor cells (MDSC) is an important mechanism of tumor immune evasion. Cyclophosphamide (CTX) has also been shown in non-tumor bearing animals to causeExpand
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A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells.
We recently demonstrated that human BM cells can be treated in vitro with defined growth factors to induce the rapid generation of myeloid-derived suppressor cells (MDSCs), hereafter defined asExpand
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Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis.
Chronic stress is associated with hormonal changes that are known to affect multiple systems, including the immune and endocrine systems, but the effects of stress on cancer growth and progressionExpand
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Myeloid-derived Suppressor Cells in Cancer Patients: A Clinical Perspective
Myeloid-derived suppressor cells (MDSCs) represent a heterogenous collection of immature myeloid cells endowed with suppressive function on the immune response. Their presence has been extensivelyExpand
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Myeloid-Derived Suppressor Cells in Cancer
Immune evasion is an emerging hallmark of cancer. Many cancers evade the immune system through the overproduction of a wide array of immunosuppressive cells and cytokines, which not only inhibit theExpand
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The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naïve recipient mice.
We have recently reported that the toll-like receptor 3 (TLR3) agonist poly(I:C) induces adjuvant effects to post vaccination CD8+ T cells responses through rapid induction of innate mediators,Expand
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PI3-K/Akt-mediated anoikis resistance of human osteosarcoma cells requires Src activation.
Considerable advances in understanding the mechanisms associated with anoikis resistance of normal and malignant epithelial cells have been made. However, little is still known about the pathwaysExpand
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Recovery from Cyclophosphamide-Induced Lymphopenia Results in Expansion of Immature Dendritic Cells Which Can Mediate Enhanced Prime-Boost Vaccination Antitumor Responses In Vivo When Stimulated with
Recent preclinical studies suggest that vaccination following adoptive transfer of CD8+ T cells into a lymphopenic host can augment the therapeutic antitumor responses of the transferred cells.Expand
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Langerhans cell histiocytosis of the female genital tract: a literature review.
Langerhans cell histiocytosis (LCH) is a rare malignant disease involving the accumulation of a monoclonal proliferation of cells in various organs, that phenotypically resemble Langerhans cellsExpand
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Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer
The epidermal growth factor receptor (EGFR) is a member of the HER/ERB-B family of transmembrane receptor kinases. Overexpression of EGFR confers advantages in cell proliferation, survival, andExpand
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