NF-Kappa-B Essential Modulator

Known as: IKK-gamma, Ikb Kinase-Associated Protein 1, Ikb Kinase Subunit Gamma 
NF-kappa-B essential modulator (419 aa, ~48 kDa) is encoded by the human IKBKG gene. This protein plays a role in the mediation of signal… (More)
National Institutes of Health

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6 relations
IKBKG geneIKBKG wt AlleleIkappaB kinaseImmune response
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Papers overview

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Highly Cited
2011
Highly Cited
2011
SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis
SHARPIN is a ubiquitin-binding and ubiquitin-like-domain-containing protein which, when mutated in mice, results in immune system… (More)
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Highly Cited
2010
Highly Cited
2010
RIPK1 is not essential for TNFR1-induced activation of NF-κB
On TNF binding, receptor-interacting protein kinase 1 (RIPK1) is recruited to the cytoplasmic domain of TNFR1, at which it… (More)
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Highly Cited
2009
Highly Cited
2009
Involvement of linear polyubiquitylation of NEMO in NF-κB activation
Nuclear factor-κB (NF-κB) is a key transcription factor in inflammatory, anti-apoptotic and immune processes. The ubiquitin… (More)
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Highly Cited
2007
Highly Cited
2007
CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation.
G protein-coupled receptors (GPCRs) play pivotal roles in regulating various cellular functions. Although many GPCRs induce NF… (More)
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Highly Cited
2007
Highly Cited
2007
A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-γ transactivation
Histone modifications induced by activated signalling cascades are crucial to cell-lineage decisions. Osteoblast and adipocyte… (More)
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Highly Cited
2006
Highly Cited
2006
PIASy mediates NEMO sumoylation and NF-κB activation in response to genotoxic stress
Protein modification by SUMO (small ubiquitin-like modifier) is an important regulatory mechanism for multiple cellular processes… (More)
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Review
2006
Review
2006
Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models
The nuclear factor-κB (NF-κB) signalling pathway serves a crucial role in regulating the transcriptional responses of… (More)
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Highly Cited
2003
Highly Cited
2003
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB
Protein modification by the conjugation of ubiquitin moieties—ubiquitination—plays a major part in many biological processes… (More)
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Highly Cited
2002
Highly Cited
2002
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.
The lymphotoxin-beta receptor (LTbetaR) plays critical roles in inflammation and lymphoid organogenesis through activation of NF… (More)
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Highly Cited
1998
Highly Cited
1998
Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation.
We have characterized a flat cellular variant of HTLV-1 Tax-transformed rat fibroblasts, 5R, which is unresponsive to all tested… (More)
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