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NCOA1 protein, human

Known as: bHLHe74, Class E Basic Helix-Loop-Helix Protein 74, F-SRC-1 
Nuclear receptor coactivator 1 (1441 aa, ~157 kDa) is encoded by the human NCOA1 gene. This protein is involved in the modulation of hormone… 
National Institutes of Health

Related topics

Related topics

15 relations
Androgen Receptor Regulation PathwayCell NucleusChromatin Remodeling Complex and Coactivator PathwayGenes, Regulator

Broader (1)

nuclear receptor coactivator 1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2000
Review
2000
HIF-1 and human disease: one highly involved factor.
Oxygen homeostasis represents an important organizing principle for human development and physiology. The essential requirement… 
Highly Cited
2000
Highly Cited
2000
Redox-Regulated Recruitment of the Transcriptional Coactivators CREB-Binding Protein and SRC-1 to Hypoxia-Inducible Factor 1α
ABSTRACT Hypoxia-inducible factor 1α (HIF-1α) functions as a transcription factor that is activated by decreased cellular oxygen… 
Highly Cited
2000
Highly Cited
2000
The Opposing Transcriptional Activities of the Two Isoforms of the Human Progesterone Receptor Are Due to Differential Cofactor Binding
ABSTRACT The human progesterone receptor (PR) exists as two functionally distinct isoforms, hPRA and hPRB. hPRB functions as a… 
Highly Cited
1998
Highly Cited
1998
The Steroid Receptor Coactivator-1 Contains Multiple Receptor Interacting and Activation Domains That Cooperatively Enhance the Activation Function 1 (AF1) and AF2 Domains of Steroid Receptors*
Steroid receptors are ligand-inducible transcription factors, and their association with steroid receptor coactivators (SRCs… 
Highly Cited
1997
Highly Cited
1997
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
The binding of lipophilic hormones, retinoids and vitamins to members of the nuclear-receptor superfamily modifies the DNA… 
Highly Cited
1997
Highly Cited
1997
Steroid receptor coactivator-1 is a histone acetyltransferase
Steroid receptors and coactivator proteins are thought to stimulate gene expression by facilitating the assembly of basal… 
Highly Cited
1997
Highly Cited
1997
TRAM-1, A Novel 160-kDa Thyroid Hormone Receptor Activator Molecule, Exhibits Distinct Properties from Steroid Receptor Coactivator-1*
Nuclear hormone receptors (NRs) are ligand-dependent transcription factors that regulate target gene transcription. We report the… 
Review
1997
Review
1997
Role of co-activators and co-repressors in the mechanism of steroid/thyroid receptor action.
Steroid/thyroid hormone receptors are ligand-dependent transcription factors that regulate diverse aspects of growth, development… 
Highly Cited
1997
Highly Cited
1997
Interaction between the Amino- and Carboxyl-terminal Regions of the Rat Androgen Receptor Modulates Transcriptional Activity and Is Influenced by Nuclear Receptor Coactivators*
Identical N-terminal deletions in the wild-type rat androgen receptor (rAR) and a constitutively active rAR (ARΔ641–902) devoid… 
Highly Cited
1996
Highly Cited
1996
The nuclear hormone receptor coactivator SRC-1 is a specific target of p300.
p300 and its family member, CREB-binding protein (CBP), function as key transcriptional coactivators by virtue of their… 
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