T. Spencer

Publications422
h-index90
Citations28,117
Highly Influential Citations1,364
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Board-invited review: intrauterine growth retardation: implications for the animal sciences.
Intrauterine growth retardation (IUGR), defined as impaired growth and development of the mammalian embryo/fetus or its organs during pregnancy, is a major concern in domestic animal production.… Expand
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Arginine metabolism and nutrition in growth, health and disease
Abstractl-Arginine (Arg) is synthesised from glutamine, glutamate, and proline via the intestinal-renal axis in humans and most other mammals (including pigs, sheep and rats). Arg degradation occurs… Expand
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Steroid receptor coactivator-1 is a histone acetyltransferase
Steroid receptors and coactivator proteins are thought to stimulate gene expression by facilitating the assembly of basal transcription factors into a stable preinitiation complex. What is not clear,… Expand
  • 1,257
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Developmental Biology of Uterine Glands1
Abstract All mammalian uteri contain endometrial glands that synthesize or transport and secrete substances essential for survival and development of the conceptus (embryo/fetus and associated… Expand
  • 315
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Maternal nutrition and fetal development.
Nutrition is the major intrauterine environmental factor that alters expression of the fetal genome and may have lifelong consequences. This phenomenon, termed "fetal programming," has led to the… Expand
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Evidence for Placental Abnormality as the Major Cause of Mortality in First-Trimester Somatic Cell Cloned Bovine Fetuses1
Abstract The production of cloned animals is, at present, an inefficient process. This study focused on the fetal losses that occur between Days 30–90 of gestation. Fetal and placental… Expand
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Implantation mechanisms: insights from the sheep.
Implantation in all mammals involves shedding of the zona pellucida, followed by orientation, apposition, attachment and adhesion of the blastocyst to the endometrium. Endometrial invasion does not… Expand
  • 282
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Conceptus signals for establishment and maintenance of pregnancy
  • T. Spencer, F. Bazer
  • Biology, Medicine
  • Reproductive biology and endocrinology : RB&E
  • 5 July 2004
Establishment and maintenance of pregnancy results from signaling by the conceptus (embryo/fetus and associated extraembryonic membranes) and requires progesterone produced by the corpus luteum (CL).… Expand
  • 303
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  • PDF
Comparative aspects of implantation.
Uterine receptivity to implantation of blastocysts in mammals includes hatching from zona pellucida, precontact with uterine luminal (LE) and superficial glandular (sGE) epithelia and orientation of… Expand
  • 299
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  • PDF
Endometrial Glands Are Required for Preimplantation Conceptus Elongation and Survival1
Abstract Endometrial glands secrete molecules hypothesized to support conceptus growth and development. In sheep, endometrial gland morphogenesis occurs postnatally and can be epigenetically ablated… Expand
  • 300
  • 17