FAQ

NAD(P)H Dehydrogenase (Quinone)

Known as: Diaphorase, DT, Reductase, Menadione, NAD(P)H Dehydrogenase (Quinone) [Chemical/Ingredient] 
A flavoprotein that reversibly catalyzes the oxidation of NADH or NADPH by various quinones and oxidation-reduction dyes. The enzyme is inhibited by… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1953-2018
0204019532017

Related topics

Related topics

22 relations
CRYZ geneElectron Transport Complex IElectron Transport Complex IIFMN reductase
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Narrower (2)

NAD(P)H dehydrogenase (quinone) 1, humanVitamin K Reductase

Broader (2)

NADH, NADPH OxidoreductasesQuinone Reductases

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
NAD(P)H Dehydrogenase (Quinone)
physiological aspects
chemical synthesis
NADPH dehydrogenase activity
NAD(P)H dehydrogenase (quinone) 1, human
standards characteristics

Papers overview

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Highly Cited
2009
Highly Cited
2009
Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion.
Brown-rot fungi such as Postia placenta are common inhabitants of forest ecosystems and are also largely responsible for the… (More)
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Highly Cited
2002
Highly Cited
2002
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Electrophiles formed during metabolic activation of chemical carcinogens and reactive oxygen species generated from endogenous… (More)
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Highly Cited
2001
Highly Cited
2001
Role of transcription factor Nrf2 in the induction of hepatic phase 2 and antioxidative enzymes in vivo by the cancer chemoprotective agent, 3H-1, 2-dimethiole-3-thione.
BACKGROUND The induction of phase 2 enzymes by dithiolethiones such as oltipraz is an effective means for achieving protection… (More)
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Highly Cited
1997
Highly Cited
1997
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens.
Induction of phase 2 detoxication enzymes [e.g., glutathione transferases, epoxide hydrolase, NAD(P)H: quinone reductase, and… (More)
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Highly Cited
1995
Highly Cited
1995
Parallel induction of heme oxygenase-1 and chemoprotective phase 2 enzymes by electrophiles and antioxidants: regulation by upstream antioxidant-responsive elements (ARE).
BACKGROUND Heme oxygenase (HO; EC 1.14.99.3) catalyzes the conversion of heme to biliverdin, which is reduced enzymatically to… (More)
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Highly Cited
1992
Highly Cited
1992
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
Consumption of vegetables, especially crucifers, reduces the risk of developing cancer. Although the mechanisms of this… (More)
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Highly Cited
1992
Highly Cited
1992
NAD(P)H:quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity.
NAD(P)H:quinone oxidoreductase (DT-diaphorase; DTD) is an obligate two-electron reductase which may play a role in the… (More)
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Highly Cited
1991
Highly Cited
1991
The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity.
We have characterized further the antioxidant responsive element (ARE) identified in the 5'-flanking region of the rat… (More)
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1988
1988
The nitroreductase enzyme in Walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase…
A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4… (More)
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Highly Cited
1980
Highly Cited
1980
Increase of NAD(P)H:quinone reductase by dietary antioxidants: possible role in protection against carcinogenesis and toxicity.
2(3)-tert-Butyl-4-hydroxyanisole (BHA) is one of several widely used antioxidant food additives that protect against chemical… (More)
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