N-desmethylflunitrazepam

Known as: N-demethylflunitrazepam, Norflunitrazepam, desmethylflunitrazepam 
 
National Institutes of Health

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Flunitrazepam
analogs & derivatives

Papers overview

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2016
2016
Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam.
Designer benzodiazepines represent an emerging class of new psychoactive substances. While other classes of new psychoactive… (More)
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2012
2012
The evaluation of the applicability of a high pH mobile phase in ultrahigh performance liquid chromatography tandem mass spectrometry analysis of benzodiazepines and benzodiazepine-like hypnotics in…
A sensitive liquid chromatography tandem mass spectrometry method was developed and validated for simultaneous detection of… (More)
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2008
2008
Buprenorphine alters desmethylflunitrazepam disposition and flunitrazepam toxicity in rats.
High-dosage buprenorphine (BUP) consumed concomitantly with benzodiazepines (BZDs) including flunitrazepam (FZ) may cause life… (More)
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2002
2002
[Fatal outcome of poisoning with the benzodiazepines flunitrazepam and diazepam].
On a wintry day a 29-year-old woman was found dead beside her car showing head injuries and signs of hypothermia. Several empty… (More)
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2001
2001
Flunitrazepam metabolism by cytochrome P450S 2C19 and 3A4.
We have identified CYP2C19 and CYP3A4 as the principal cytochrome P450s involved in the metabolism of flunitrazepam to its major… (More)
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2001
2001
CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
The kinetics of flunitrazepam (FNTZ) N-demethylation to desmethylflunitrazepam (DM FNTZ), and 3-hydroxylation to 3… (More)
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1999
1999
Flunitrazepam oxidative metabolism in human liver microsomes: involvement of CYP2C19 and CYP3A4.
The aims were to examine the kinetics of the oxidative metabolism of flunitrazepam in vitro when flunitrazepam was dissolved in… (More)
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1999
1999
On-line immunoaffinity extraction and HPLC analysis of flunitrazepam and its main metabolites in serum.
A sensitive, simple, and rapid method for the determination of flunitrazepam and its major metabolites (7-aminoflunitrazepam, 7… (More)
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1981
1981
Photochemical activity of 7-nitro-1,4-benzodiazepines
The photochemical activity of nitrazepam, clonazepam and flunitrazepam has been investigated. These closely structurally related… (More)
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1978
1978
Zur Analytik von Flunitrazepam (Rohypnol), einem neuen Benzodiazepinderivat, unter besonderer Berücksichtigung der Metaboliten
The article describes analytical data (TLC, GLC, IR, UV and MS) of flunitrazepam, 7-amino-flunitrazepam, desmethylflunitrazepam… (More)
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