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A method for estimating the probability of adverse drug reactions
TLDR
It was shown that the ADR probability scale has consensual, content, and concurrent validity and may be applicable to postmarketing drug surveillance.
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Sedative hypnotics in older people with insomnia: meta-analysis of risks and benefits
TLDR
Improvements in sleep with sedative use are statistically significant, but the magnitude of effect is small, and the increased risk of adverse events is statistically significant and potentially clinically relevant in older people at risk of falls and cognitive impairment.
View on Wolters Kluwer
Functional neuroanatomical substrates of altered reward processing in major depressive disorder revealed by a dopaminergic probe.
TLDR
Dopamine-related neuroanatomical substrates are involved in altered reward processing in major depressive disorder, shedding light on the neurobiology of the anhedonic symptoms in MDD and suggesting these substrates as future therapeutic targets.
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The role of the brain reward system in depression
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Prescription opioid abuse in patients presenting for methadone maintenance treatment.
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A Clinical Scale to Assess Benzodiazepine Withdrawal
TLDR
The CIWA-B is proposed as an instrument to assess and monitor benzodiazepine-like withdrawal, a scale of 20 five-point items and two additional values designed to distinguish withdrawal from prewithdrawal.
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CYP2D6 phenotype determines the metabolic conversion of hydrocodone to hydromorphone
TLDR
The data establish the importance of CYP2D6 in the formation of hydromorphone from hydrocodone and suggest that the activity of this enzyme may limit the abuse liability of hydrocODone.
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Probing brain reward system function in major depressive disorder: altered response to dextroamphetamine.
TLDR
The results suggest the presence of a hypersensitive response is present in the brain reward system of depressed patients, which may reflect a hypofunctional state and may provide a novel pathophysiologic and therapeutic target for future studies.
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Inhibition of human cytochrome P450 2D6 (CYP2D6) by methadone.
TLDR
In microsomes prepared from three human livers, methadone competitively inhibited the O-demethylation of dextromethorphan, a marker substrate for CYP2D6, suggesting inhibition of CYP6 activity in these patients might contribute to exaggerated response or unexpected toxicity from drugs that are substrates of this enzyme.
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Oral D‐amphetamine causes prolonged displacement of [11C]raclopride as measured by PET
TLDR
In conclusion, orally administered D‐amphetamine caused a reliable and prolonged [11C]raclopride displacement, the magnitude of which is similar to that observed after intravenous administration.
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