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Matrix effect in bio-analysis of illicit drugs with LC-MS/MS: Influence of ionization type, sample preparation, and biofluid
TLDR
The results indicated that both ionization types showed matrix effect, but ESI was more susceptible than APCI, while SPE was necessary for extensive clean up of plasma prior to LC-APCI-MS/MS. Expand
Folate fortification of rice by metabolic engineering
TLDR
F folate biofortification of rice seeds is achieved by overexpressing two Arabidopsis thaliana genes of the pterin and para-aminobenzoate branches of the folate biosynthetic pathway from a single locus. Expand
Analysis of multiple endocrine disruptors in environmental waters via wide-spectrum solid-phase extraction and dual-polarity ionization LC-ion trap-MS/MS.
TLDR
An analytical method for the determination of 35 endocrine disrupting chemicals (EDCs) present in the aquatic environment was developed and validated and stability experiments showed no significant loss or deterioration for any of the analytes. Expand
Therapeutic drug monitoring of old and newer anti-epileptic drugs
TLDR
This review shows that TDM may be helpful for a number of these newer drugs, including carbamazepine, clobazam, clonazepam, ethosuximide and zonisamide, which have undergone extensive clinical studies. Expand
Interpretation of a 3,4-methylenedioxymethamphetamine (MDMA) blood level: discussion by means of a distribution study in two fatalities.
TLDR
The results suggest that, if a peripheral blood sample is not available and when putrefaction is not too pronounced, vitreous humour and iliopsoas muscle can be valuable specimens for toxicological analysis and confirm that peripheral blood sampling remains "the golden standard". Expand
A field study on 8 pharmaceuticals and 1 pesticide in Belgium: removal rates in waste water treatment plants and occurrence in surface water.
TLDR
The applicability of a previously developed LC-MS/MS method is demonstrated by evaluating in waste water and surface water samples from Belgium the occurrence of 8 pharmaceuticals and 1 pesticide and the pesticide propiconazole was found in comparable concentrations as in effluent, suggesting potential introduction by direct seeping of water from rural grounds. Expand
Development and validation of a liquid chromatography-tandem mass spectrometry assay for the quantification of docetaxel and paclitaxel in human plasma and oral fluid.
TLDR
A sensitive and robust method was obtained, which fulfilled all validation criteria, and accuracy varied from 91.3 to 103.6%, and imprecision did not exceed 12.7% for all analytes in plasma and oral fluid. Expand
pH stability of individual folates during critical sample preparation steps in prevision of the analysis of plant folates.
TLDR
An LC-MS/MS method with isotopically labelled 5-methyltetrahydrofolate and folic acid as internal standards has been developed with enhanced sensitivity using a Chromolith RP-18 column and provides useful information for the analysis of folates in the future as well as for the interpretation of quantitative results from earlier work. Expand
Folates and Folic Acid: From Fundamental Research Toward Sustainable Health
TLDR
The state-of-the-art of folate biosynthesis, catabolism, and salvage is provided and the agroeconomical aspect of biofortified crop plants is discussed. Expand
Folate biofortification in food plants.
TLDR
The genes and enzymes of folate synthesis are sufficiently understood to enable metabolic engineering of the pathway, and results from pilot engineering studies in plants (and bacteria) are encouraging. Expand
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