N-acetylgalactosamine-6-sulfatase activity

Known as: N-acetyl-D-galactosamine-6-sulfate 6-sulfohydrolase activity, acetylgalactosamine 6-sulfatase activity, N-acetylgalactosamine-6-sulfate sulfatase activity 
Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6… (More)
National Institutes of Health

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3 relations
ChondroitinasesHyaluronidase

Broader (1)

chondroitinsulfatase activity

Papers overview

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Highly Cited
2010
Highly Cited
2010
Perineuronal net formation and structure in aggrecan knockout mice
Perineuronal nets (PNNs) are specialized substructures of the neural extracellular matrix (ECM) which envelop the cell soma and… (More)
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Highly Cited
2009
Highly Cited
2009
Perineuronal nets protect fear memories from erasure.
In adult animals, fear conditioning induces a permanent memory that is resilient to erasure by extinction. In contrast, during… (More)
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Highly Cited
2009
Highly Cited
2009
Chondroitinase ABC treatment opens a window of opportunity for task-specific rehabilitation
Chondroitinase ABC treatment promotes spinal cord plasticity. We investigated whether chondroitinase-induced plasticity combined… (More)
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Highly Cited
2008
Highly Cited
2008
Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and…
Increased chondroitin sulfate proteoglycan (CSPG) expression in the vicinity of a spinal cord injury (SCI) is a primary… (More)
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Review
2006
Review
2006
Hyaluronidases: their genomics, structures, and mechanisms of action.
The hyaluronidases (Hyals) are classes of enzymes that degrade, predominantly, hyaluronan (HA). The term “hyaluronidase” is… (More)
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Review
2005
Review
2005
Critical period mechanisms in developing visual cortex.
Binocular vision is shaped by experience during a critical period of early postnatal life. Loss of visual acuity following… (More)
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Highly Cited
2005
Highly Cited
2005
Chondroitinase ABCI improves locomotion and bladder function following contusion injury of the rat spinal cord.
Chondroitin sulfate proteoglycans are synthesized and deposited in the spinal cord following injury. These proteoglycans may… (More)
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Highly Cited
2003
Highly Cited
2003
Axonal regeneration of Clarke’s neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC
We have previously demonstrated that enzymatic digestion of chondroitin sulfate proteoglycan (CSPG) at the scar promotes the… (More)
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Highly Cited
1998
Highly Cited
1998
Degradation of Chondroitin Sulfate Proteoglycan Enhances the Neurite-Promoting Potential of Spinal Cord Tissue
The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been… (More)
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Highly Cited
1998
Highly Cited
1998
Neuronal matrix metalloproteinase-2 degrades and inactivates a neurite-inhibiting chondroitin sulfate proteoglycan.
Chondroitin sulfate proteoglycans (CSPGs) are implicated in the regulation of axonal growth. We previously reported that the… (More)
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