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Essentials of Glycobiology
General principles - historical background and overview saccharide structure and nomenclature evolution of glycan diversity protein-glycan Interactions exploring the biological roles of glycans… Expand
Order out of chaos: assembly of ligand binding sites in heparan sulfate.
Virtually every cell type in metazoan organisms produces heparan sulfate. These complex polysaccharides provide docking sites for numerous protein ligands and receptors involved in diverse biological… Expand
Heparan sulphate proteoglycans fine-tune mammalian physiology
Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices. Studies of model organisms and human diseases have… Expand
Heparan sulfate proteoglycans.
- Stéphane Sarrazin, William C. Lamanna, J. Esko
- Biology, Medicine
- Cold Spring Harbor perspectives in biology
- 1 July 2011
Heparan sulfate proteoglycans are found at the cell surface and in the extracellular matrix, where they interact with a plethora of ligands. Over the last decade, new insights have emerged regarding… Expand
Dengue virus infectivity depends on envelope protein binding to target cell heparan sulfate
Dengue virus is a human pathogen that has reemerged as an increasingly important public health threat. We found that the cellular receptor utilized by dengue envelope protein to bind to target cells… Expand
Molecular diversity of heparan sulfate.
Heparan sulfate (HS) appeared early in metazoan evolution. As such, many of the structural motifs (variably sulfated disaccharide subunits) that characterize HS (and heparin) were established early… Expand
Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
The role of low affinity, heparin-like binding sites for basic fibroblast growth factor (bFGF) was investigated in CHO cells mutant in their metabolism of glycosaminoglycans. Heparan… Expand
Animal cell mutants defective in glycosaminoglycan biosynthesis.
- J. Esko, T. Stewart, W. Taylor
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 May 1985
We have obtained Chinese hamster ovary cell mutants defective in the biosynthesis of glycosaminoglycans by screening replicate colonies immobilized on polyester cloth. Depending upon the strain, the… Expand
Proteoglycans and Sulfated Glycosaminoglycans
A Novel Role for 3-O-Sulfated Heparan Sulfate in Herpes Simplex Virus 1 Entry
Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient for… Expand